Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4487665..4488709 Replicon chromosome
Accession NZ_AP022261
Organism Escherichia coli strain WP8-S18-ESBL-07

Toxin (Protein)


Gene name panT Uniprot ID A0A7Z8DXL5
Locus tag H7R25_RS21400 Protein ID WP_021563277.1
Coordinates 4487665..4488213 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag H7R25_RS21405 Protein ID WP_000287252.1
Coordinates 4488236..4488709 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R25_RS21355 4483184..4484062 + 879 WP_001342658.1 phosphoadenosine phosphosulfate reductase family protein -
H7R25_RS21360 4484059..4484262 + 204 WP_000156999.1 hypothetical protein -
H7R25_RS21365 4484255..4484494 + 240 WP_000476213.1 hypothetical protein -
H7R25_RS21370 4484491..4485135 + 645 WP_033813558.1 hypothetical protein -
H7R25_RS21375 4485132..4485731 + 600 WP_032239441.1 ead/Ea22-like family protein -
H7R25_RS21380 4485733..4485996 + 264 WP_032239443.1 hypothetical protein -
H7R25_RS21385 4486007..4486750 + 744 WP_032239444.1 DUF551 domain-containing protein -
H7R25_RS21390 4486750..4487322 + 573 WP_033813643.1 3'-5' exoribonuclease -
H7R25_RS21395 4487359..4487631 + 273 WP_001093913.1 pyocin activator PrtN family protein -
H7R25_RS21400 4487665..4488213 - 549 WP_021563277.1 hypothetical protein Toxin
H7R25_RS21405 4488236..4488709 - 474 WP_000287252.1 SocA family protein Antitoxin
H7R25_RS21410 4488996..4489118 - 123 WP_001300034.1 hypothetical protein -
H7R25_RS21415 4489481..4490443 - 963 WP_000912582.1 DUF2713 family protein -
H7R25_RS21420 4490761..4491276 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
H7R25_RS21425 4491318..4491527 - 210 WP_001030593.1 CsbD family protein -
H7R25_RS21430 4491643..4492968 - 1326 WP_001545103.1 MATE family efflux transporter DinF -
H7R25_RS21435 4493041..4493649 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4435186..4488709 53523


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 19952.40 Da        Isoelectric Point: 4.5662

>T35135 WP_021563277.1 NZ_AP022261:c4488213-4487665 [Escherichia coli]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQVFKSAFEPSNHESDDDSSSENKAILEAEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Download         Length: 549 bp

>T35135 NZ_AP022261:c4488213-4487665 [Escherichia coli]
ATGTCTCACAATTCAGATATCTATAAACTTATCGGAGCGGCCGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTCTACTGACAGTCAAGAACAGGTTTTTAAATCTGCATTTGAGCCGTCTAATCATGAGAGCGACGATGATTCTTCTTCAG
AAAATAAAGCTATTCTGGAGGCAGAAGAGTTTGGTTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGAACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGGGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAGCTTCGGACAAAAATGGCCTCATTCACGGTTTGGTTTATGTCGTGTTGGTGCTTATTCGTTGTCGCAATGTTTA
CATCGTTTCTTATTGCACATGAAGGAAAGCCTCCAGTTGAAGCGATCGTTGCATTACTAGGTACAAGTACAATTAGTATT
GTTGGTTTGGTTGGTTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATAGTGATAAAGAAAAATAA

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT35135 WP_000287252.1 NZ_AP022261:c4488709-4488236 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp

>AT35135 NZ_AP022261:c4488709-4488236 [Escherichia coli]
ATGTACAGTCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAATGAATGTGTCTCCGCGT
GGAAGTACGGTCCAGTTATTCCTGGAATGTACGATGCTTTCAAAGACTATGGGAATAAACCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATCGTTACTATGGATCCGCAAGCAGAGAGCATTATCGGGGCTGTTTATAAGTTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAGCTTATAATGGTATTGGCTCGTCAA
TCATCTCAAATGATGCGATCAAGGCTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z8DXL5

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References