Detailed information of TA system TA035062

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4600948..4602521
• Replicon: chromosome
• Accession: NZ_AP022241
• Organism: Aeromonas caviae strain WP8-S18-CRE-01

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A3G9IWM9
• Locus tag: H7R78_RS21460
• Protein ID: WP_049637213.1
• Coordinates: 4600948..4602267 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: H7R78_RS21465
• Protein ID: WP_017410478.1
• Coordinates: 4602267..4602521 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R78_RS21445	4596852..4597616	+	765	WP_049637211.1	ATP-binding cassette domain-containing protein	-
H7R78_RS21450	4597648..4598550	+	903	WP_049637230.1	ABC transporter substrate-binding protein	-
H7R78_RS21455	4598547..4600529	+	1983	WP_049637212.1	Fe(3+)-hydroxamate ABC transporter permease FhuB	-
H7R78_RS21460	4600948..4602267	-	1320	WP_049637213.1	type II toxin-antitoxin system HipA family toxin	Toxin
H7R78_RS21465	4602267..4602521	-	255	WP_017410478.1	helix-turn-helix domain-containing protein	Antitoxin
H7R78_RS21470	4602754..4603095	-	342	WP_197725296.1	DUF86 domain-containing protein	-
H7R78_RS21475	4603168..4604318	+	1151	WP_102948979.1	IS3 family transposase	-
H7R78_RS21480	4604337..4604630	-	294	Protein_4134	site-specific integrase	-
H7R78_RS21485	4604793..4606154	-	1362	WP_010672278.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49559.53 Da
• Isoelectric Point: 6.5054

>T35062 WP_049637213.1 NZ_AP022241:c4602267-4600948 [Aeromonas caviae]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELKQILTSYKSGIPLGMVREQEEFRISIAGVQEKTA
LLYLDGLWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMETLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYSIEQIFPRHFFQTAKTVGFERSAMEEILTELANSV
DDVIERVTQQLPADFPDTISSTILEGLKARSARLIKGWD

Nucleotide

• Length: 1320 bp

>T35062 NZ_AP022241:c4602267-4600948 [Aeromonas caviae]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTAGGCACATTCACCAAAACTACCAGCGGTGCCCATCAGTTTCA
GTACCATGAGTCATGGCTAGCACAACCGGGCAGCCGTCCGATCTCACTCTCCATGCCATTGCGCCATCAGGCCTACCGGG
GCGATGAAGCCTATAACTTCTTCGACAACCTGCTGCCAGATAATACGGAGGTGAGGAACAGGGTTGTAGCACGCTATCAA
GCGGCATCAACTCAGCCCTTCGATCTGCTCAGTTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
ACACGATGTTCCAGATGTCAGGCGAATCGACTACAAGGCCCTTTCCGATGACGAGCTCAAGCAGATCCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGGGAACAAGAGGAGTTTCGGATCTCTATCGCCGGGGTGCAAGAAAAGACTGCG
CTGCTCTATCTCGATGGCCTTTGGTACCTGCCACTCAACGCAACGCCGACAACCCACATTATCAAACTCCCTATCGGCAA
GATTGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACTCTGATTGCCAAGGAGT
TTGGTCTACCCGTACCTCACTGCTTCATGATGCAGGTTGGCCAGGTCAAAGCACTGGCTGTTGAACGCTTCGACAGACGT
TACGCTGCCGATCGCAGTTGGATAATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAGCCATGGAGGACCAGGGATCACTGACATCATGGAAACCTTGCTGGGCTCTGCGACACCAGAACAGGATCGCT
ACCTGTTCATGAAATCTCAGGTCCTGTTCTGGCTGCTGGCAGCCACCGATGGCCATGCAAAGAACTTCTCGGTCTTTATT
GAACCGGAAGGGCGTTTTCGCCTGACCCCTTTTTACGACATCCTATCTGTCTATCCAGTGTTTGGCGGCCGAGGCCTCAA
CCGAAGGGACGCCAAGCTCGCTATGGGCCTAGCAAGCAGCAAGGGAAAGAAGTACTCCATTGAGCAGATATTCCCGCGTC
ATTTCTTCCAAACGGCAAAAACTGTGGGATTTGAGCGTTCTGCTATGGAAGAGATCCTGACAGAACTGGCCAACTCCGTT
GATGATGTTATTGAGCGCGTTACCCAGCAATTGCCAGCAGACTTCCCCGATACCATCAGCAGCACCATTCTAGAGGGCCT
AAAAGCCCGCTCAGCCAGGCTGATAAAGGGTTGGGATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9293.62 Da
• Isoelectric Point: 7.9834

>AT35062 WP_017410478.1 NZ_AP022241:c4602521-4602267 [Aeromonas caviae]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Nucleotide

• Length: 255 bp

>AT35062 NZ_AP022241:c4602521-4602267 [Aeromonas caviae]
ATGAAAGTAACCAGCGCCAAGCAGCTGAGCGCCTGTATCAAGGATGCCAGGCTTTCTCAAAAGCTCTCTCAAGGCAAAGT
GGCCGAGAAAGTGGGGATTAGGCAAGACACAGTCTCCAGCTTCGAGCTCAATCCTGAGTCCACCAAGCTGGAAACCCTGT
TCAAGATCCTCGCAGCACTCGAATTGTCAGTGGATATCAAACCCCGCAATGAGTCATCCGAGAGTCCGGCATCGGGCTGG
AAGGAGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: A0A3G9IWM9