Detailed information of TA system TA034952

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4341823..4343396
• Replicon: chromosome
• Accession: NZ_AP022214
• Organism: Aeromonas caviae strain WP8-S17-ESBL-03

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A3G9IWM9
• Locus tag: H7K57_RS20165
• Protein ID: WP_049637213.1
• Coordinates: 4341823..4343142 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: H7K57_RS20170
• Protein ID: WP_017410478.1
• Coordinates: 4343142..4343396 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7K57_RS20150	4337727..4338491	+	765	WP_049637211.1	ATP-binding cassette domain-containing protein	-
H7K57_RS20155	4338523..4339425	+	903	WP_049637230.1	ABC transporter substrate-binding protein	-
H7K57_RS20160	4339422..4341404	+	1983	WP_049637212.1	Fe(3+)-hydroxamate ABC transporter permease FhuB	-
H7K57_RS20165	4341823..4343142	-	1320	WP_049637213.1	type II toxin-antitoxin system HipA family toxin	Toxin
H7K57_RS20170	4343142..4343396	-	255	WP_017410478.1	helix-turn-helix domain-containing protein	Antitoxin
H7K57_RS20175	4343629..4343970	-	342	WP_197725296.1	DUF86 domain-containing protein	-
H7K57_RS20180	4344043..4345193	+	1151	WP_102948979.1	IS3 family transposase	-
H7K57_RS20185	4345212..4345505	-	294	Protein_3880	site-specific integrase	-
H7K57_RS20190	4345668..4347029	-	1362	WP_010672278.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49559.53 Da
• Isoelectric Point: 6.5054

>T34952 WP_049637213.1 NZ_AP022214:c4343142-4341823 [Aeromonas caviae]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELKQILTSYKSGIPLGMVREQEEFRISIAGVQEKTA
LLYLDGLWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMETLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYSIEQIFPRHFFQTAKTVGFERSAMEEILTELANSV
DDVIERVTQQLPADFPDTISSTILEGLKARSARLIKGWD

Nucleotide

• Length: 1320 bp

>T34952 NZ_AP022214:c4343142-4341823 [Aeromonas caviae]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTAGGCACATTCACCAAAACTACCAGCGGTGCCCATCAGTTTCA
GTACCATGAGTCATGGCTAGCACAACCGGGCAGCCGTCCGATCTCACTCTCCATGCCATTGCGCCATCAGGCCTACCGGG
GCGATGAAGCCTATAACTTCTTCGACAACCTGCTGCCAGATAATACGGAGGTGAGGAACAGGGTTGTAGCACGCTATCAA
GCGGCATCAACTCAGCCCTTCGATCTGCTCAGTTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
ACACGATGTTCCAGATGTCAGGCGAATCGACTACAAGGCCCTTTCCGATGACGAGCTCAAGCAGATCCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGGGAACAAGAGGAGTTTCGGATCTCTATCGCCGGGGTGCAAGAAAAGACTGCG
CTGCTCTATCTCGATGGCCTTTGGTACCTGCCACTCAACGCAACGCCGACAACCCACATTATCAAACTCCCTATCGGCAA
GATTGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACTCTGATTGCCAAGGAGT
TTGGTCTACCCGTACCTCACTGCTTCATGATGCAGGTTGGCCAGGTCAAAGCACTGGCTGTTGAACGCTTCGACAGACGT
TACGCTGCCGATCGCAGTTGGATAATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAGCCATGGAGGACCAGGGATCACTGACATCATGGAAACCTTGCTGGGCTCTGCGACACCAGAACAGGATCGCT
ACCTGTTCATGAAATCTCAGGTCCTGTTCTGGCTGCTGGCAGCCACCGATGGCCATGCAAAGAACTTCTCGGTCTTTATT
GAACCGGAAGGGCGTTTTCGCCTGACCCCTTTTTACGACATCCTATCTGTCTATCCAGTGTTTGGCGGCCGAGGCCTCAA
CCGAAGGGACGCCAAGCTCGCTATGGGCCTAGCAAGCAGCAAGGGAAAGAAGTACTCCATTGAGCAGATATTCCCGCGTC
ATTTCTTCCAAACGGCAAAAACTGTGGGATTTGAGCGTTCTGCTATGGAAGAGATCCTGACAGAACTGGCCAACTCCGTT
GATGATGTTATTGAGCGCGTTACCCAGCAATTGCCAGCAGACTTCCCCGATACCATCAGCAGCACCATTCTAGAGGGCCT
AAAAGCCCGCTCAGCCAGGCTGATAAAGGGTTGGGATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9293.62 Da
• Isoelectric Point: 7.9834

>AT34952 WP_017410478.1 NZ_AP022214:c4343396-4343142 [Aeromonas caviae]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Nucleotide

• Length: 255 bp

>AT34952 NZ_AP022214:c4343396-4343142 [Aeromonas caviae]
ATGAAAGTAACCAGCGCCAAGCAGCTGAGCGCCTGTATCAAGGATGCCAGGCTTTCTCAAAAGCTCTCTCAAGGCAAAGT
GGCCGAGAAAGTGGGGATTAGGCAAGACACAGTCTCCAGCTTCGAGCTCAATCCTGAGTCCACCAAGCTGGAAACCCTGT
TCAAGATCCTCGCAGCACTCGAATTGTCAGTGGATATCAAACCCCGCAATGAGTCATCCGAGAGTCCGGCATCGGGCTGG
AAGGAGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: A0A3G9IWM9