Detailed information of TA system TA034933

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 4623267..4623862
• Replicon: chromosome
• Accession: NZ_AP022207
• Organism: Escherichia coli strain WP7-S18-ESBL-09

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: -
• Locus tag: H7R37_RS22260
• Protein ID: WP_113472337.1
• Coordinates: 4623267..4623617 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: L4JJX7
• Locus tag: H7R37_RS22265
• Protein ID: WP_001223213.1
• Coordinates: 4623611..4623862 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R37_RS22240	4618721..4619743	-	1023	WP_001361374.1	ABC transporter permease	-
H7R37_RS22245	4619757..4621259	-	1503	WP_001522399.1	sugar ABC transporter ATP-binding protein	-
H7R37_RS22250	4621392..4622348	-	957	WP_001522398.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
H7R37_RS22255	4622658..4623188	+	531	WP_000055075.1	inorganic diphosphatase	-
H7R37_RS22260	4623267..4623617	-	351	WP_113472337.1	endoribonuclease toxin ChpB	Toxin
H7R37_RS22265	4623611..4623862	-	252	WP_001223213.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
H7R37_RS22270	4624074..4624415	-	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
H7R37_RS22275	4624418..4628197	-	3780	WP_182916789.1	autotransporter assembly complex protein TamB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (6-115)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12471.44 Da
• Isoelectric Point: 6.2206

>T34933 WP_113472337.1 NZ_AP022207:c4623617-4623267 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTMVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T34933 NZ_AP022207:c4623617-4623267 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGATGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9331.64 Da
• Isoelectric Point: 4.6509

>AT34933 WP_001223213.1 NZ_AP022207:c4623862-4623611 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT34933 NZ_AP022207:c4623862-4623611 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Antitoxin

• AlphaFold DB: L4JJX7