Detailed information of TA system TA034906

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc(toxin)
• Location: 3308711..3309288
• Replicon: chromosome
• Accession: NZ_AP022188
• Organism: Aeromonas media strain WP7-W18-ESBL-02

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: H7K58_RS15140
• Protein ID: WP_182785848.1
• Coordinates: 3308890..3309288 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A6M4YTF0
• Locus tag: H7K58_RS15135
• Protein ID: WP_033137226.1
• Coordinates: 3308711..3308890 (+)
• Length: 60 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7K58_RS15095	3304174..3304662	+	489	WP_041206169.1	SsrA-binding protein SmpB	-
H7K58_RS15105	3305731..3306006	-	276	WP_043133159.1	hypothetical protein	-
H7K58_RS15110	3306003..3306911	-	909	WP_182785840.1	KilA-N domain-containing protein	-
H7K58_RS15115	3306898..3307062	-	165	WP_081250441.1	Arc family DNA-binding protein	-
H7K58_RS15120	3307211..3307495	+	285	WP_182785842.1	Arc family DNA-binding protein	-
H7K58_RS15125	3307677..3308357	+	681	WP_182785844.1	hypothetical protein	-
H7K58_RS15130	3308358..3308561	-	204	WP_182785846.1	hypothetical protein	-
H7K58_RS15135	3308711..3308890	+	180	WP_033137226.1	hypothetical protein	Antitoxin
H7K58_RS15140	3308890..3309288	+	399	WP_182785848.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
H7K58_RS15145	3309333..3311987	-	2655	WP_182788950.1	PLxRFG domain-containing protein	-
H7K58_RS15150	3312141..3312533	-	393	Protein_2918	hypothetical protein	-
H7K58_RS15155	3312687..3313379	-	693	Protein_2919	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3306003..3369225	63222

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (36-107)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14492.52 Da
• Isoelectric Point: 4.1179

>T34906 WP_182785848.1 NZ_AP022188:3308890-3309288 [Aeromonas media]
MDIIQFPPARVLEINHYILGASPGHQGPASIALLEGALGRIDNAIAYNGLNDVFLIAAKYAMAIGTAHAFSDANKRTGLA
VCLEYLSLNDFEIERDNEKLADAMVDLVLGELPEEWFADILYALWLEEQKTS

Nucleotide

• Length: 399 bp

>T34906 NZ_AP022188:3308890-3309288 [Aeromonas media]
ATGGATATCATCCAGTTTCCTCCCGCTCGGGTGCTGGAGATTAACCACTACATCCTAGGTGCGTCGCCTGGTCACCAGGG
GCCTGCCAGCATAGCGTTATTGGAGGGGGCGCTTGGCCGCATCGACAACGCCATCGCCTACAACGGGCTAAATGATGTGT
TTCTCATCGCCGCAAAGTACGCAATGGCCATCGGTACCGCTCACGCCTTTTCCGATGCCAATAAGCGCACCGGACTCGCG
GTCTGCCTTGAGTATTTATCCCTCAACGACTTCGAGATTGAAAGAGATAACGAGAAGCTGGCGGACGCTATGGTTGACCT
TGTGCTTGGCGAGCTGCCAGAAGAGTGGTTTGCCGATATCCTTTACGCGCTTTGGTTGGAAGAGCAAAAAACCTCCTGA

Antitoxin

Protein

• Length: 60 a.a.
• Molecular weight: 6788.82 Da
• Isoelectric Point: 10.1555

>AT34906 WP_033137226.1 NZ_AP022188:3308711-3308890 [Aeromonas media]
MKDNTVSNKYGLPQVQNRPQIKAEKNLCLNGEEGRQIIKSETKLTLKTHEKTFTRLADM

Nucleotide

• Length: 180 bp

>AT34906 NZ_AP022188:3308711-3308890 [Aeromonas media]
ATGAAAGACAACACCGTCAGCAACAAATATGGATTGCCACAAGTGCAGAATCGGCCACAAATCAAGGCTGAAAAGAACCT
GTGCCTGAACGGTGAAGAGGGCCGCCAGATCATCAAGTCTGAGACCAAGCTGACACTGAAGACCCACGAGAAGACCTTCA
CCCGTTTGGCTGATATGTAA

Structures

Antitoxin

• AlphaFold DB: A0A6M4YTF0