Detailed information of TA system TA034903

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 172578..173488
• Replicon: plasmid pWP7-S17-ESBL-08_1
• Accession: NZ_AP022184
• Organism: Klebsiella quasipneumoniae strain WP7-S17-ESBL-08

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A2A5MBW7
• Locus tag: H7R75_RS25605
• Protein ID: WP_023329005.1
• Coordinates: 173018..173488 (+)
• Length: 157 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A2A5MC16
• Locus tag: H7R75_RS25600
• Protein ID: WP_032731962.1
• Coordinates: 172578..173021 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R75_RS25575	168362..168700	-	339	WP_096835051.1	hypothetical protein	-
H7R75_RS25580	168899..169620	+	722	Protein_183	DUF969 domain-containing protein	-
H7R75_RS25585	169617..170603	+	987	Protein_184	DUF979 domain-containing protein	-
H7R75_RS25590	170613..171608	+	996	WP_032731961.1	DUF2891 domain-containing protein	-
H7R75_RS25595	171769..172456	+	688	Protein_186	DUF4113 domain-containing protein	-
H7R75_RS25600	172578..173021	+	444	WP_032731962.1	DUF2384 domain-containing protein	Antitoxin
H7R75_RS25605	173018..173488	+	471	WP_023329005.1	RES family NAD+ phosphorylase	Toxin
H7R75_RS25610	173599..173858	-	260	Protein_189	hypothetical protein	-
H7R75_RS25615	174553..175928	+	1376	WP_094955560.1	IS3 family transposase	-
H7R75_RS25620	176177..176752	-	576	WP_032731970.1	cytochrome b/b6 domain-containing protein	-
H7R75_RS25625	176836..177804	+	969	WP_022652343.1	IS5-like element IS903B family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	mrkJ / mrkF / mrkC / mrkB / mrkA / pla	1..218891	218891

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre (16-147)

Sequences

Toxin

Protein

• Length: 157 a.a.
• Molecular weight: 17459.70 Da
• Isoelectric Point: 4.4829

>T34903 WP_023329005.1 NZ_AP022184:173018-173488 [Klebsiella quasipneumoniae]
VILYRLTKTKNLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPANWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHSDFYGIVQMAQQIPFRFDSRLKPDRK

Nucleotide

• Length: 471 bp

>T34903 NZ_AP022184:173018-173488 [Klebsiella quasipneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGAATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAATTGATCCAAAGCGCAAATATGGAT
GAATTACCGGCCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCTCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACTCTGATTTTT
ACGGGATCGTGCAGATGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16424.76 Da
• Isoelectric Point: 10.2497

>AT34903 WP_032731962.1 NZ_AP022184:172578-173021 [Klebsiella quasipneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAALKWLNEPNRALSWKVPADLIASETGAYEVIKLITRLENGVYS

Nucleotide

• Length: 444 bp

>AT34903 NZ_AP022184:172578-173021 [Klebsiella quasipneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTGCTGGGTCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAACCGGATCACTGACTGGGCCAGAATAACCC
AAAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGACTGGTACGTATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGATAAGGAAGCCGCACTGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATAGCATCCGAGACGGGAGCATATGAGG
TCATTAAGCTGATTACGCGTCTGGAGAATGGGGTGTACTCGTGA

Structures

Toxin

• AlphaFold DB: A0A2A5MBW7

Antitoxin

• AlphaFold DB: A0A2A5MC16