Detailed information of TA system TA034901

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4570672..4571185
• Replicon: chromosome
• Accession: NZ_AP022183
• Organism: Klebsiella quasipneumoniae strain WP7-S17-ESBL-08

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H7R75_RS22100
• Protein ID: WP_064190102.1
• Coordinates: 4570672..4570953 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: H7R75_RS22105
• Protein ID: WP_002886901.1
• Coordinates: 4570943..4571185 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R75_RS22085	4565714..4567369	+	1656	WP_064178460.1	alpha,alpha-phosphotrehalase	-
H7R75_RS22090	4567755..4569893	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
H7R75_RS22095	4570204..4570668	+	465	WP_064190101.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
H7R75_RS22100	4570672..4570953	-	282	WP_064190102.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H7R75_RS22105	4570943..4571185	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
H7R75_RS22110	4571263..4573173	-	1911	WP_057212387.1	BglG family transcription antiterminator	-
H7R75_RS22115	4573196..4574347	-	1152	WP_065878155.1	lactonase family protein	-
H7R75_RS22120	4574414..4575154	-	741	WP_004206507.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (18-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11031.81 Da
• Isoelectric Point: 10.1752

>T34901 WP_064190102.1 NZ_AP022183:c4570953-4570672 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNNLQQIMQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGKR
EKAAVYHQANKRL

Nucleotide

• Length: 282 bp

>T34901 NZ_AP022183:c4570953-4570672 [Klebsiella quasipneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGCTTGGCGAGACGGTCAAAAAACAGTTCAAAAA
TAATCTCCAGCAGATTATGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTGCCGGATTGCTACAAAATCAAGC
TTAAGGCGTCAGGTTATCGGCTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAAAGA
GAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT34901 WP_002886901.1 NZ_AP022183:c4571185-4570943 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT34901 NZ_AP022183:c4571185-4570943 [Klebsiella quasipneumoniae]
ATGGCCACGCTCAACGTTCGACTGGATGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTACGTCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGCGATG
GCGAAGCGGCGTTGTTACGCACCGTTCGCGAGCGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0