Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2564599..2566187 Replicon chromosome
Accession NZ_AP022183
Organism Klebsiella quasipneumoniae strain WP7-S17-ESBL-08

Toxin (Protein)


Gene name hipA Uniprot ID A0A246AZS4
Locus tag H7R75_RS12455 Protein ID WP_017900381.1
Coordinates 2564599..2565921 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2A5MFC9
Locus tag H7R75_RS12460 Protein ID WP_004205921.1
Coordinates 2565921..2566187 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R75_RS12420 2559681..2559899 + 219 WP_002904808.1 ParD-like family protein -
H7R75_RS12425 2559880..2560662 + 783 WP_023318215.1 type I methionyl aminopeptidase -
H7R75_RS12430 2560931..2562046 + 1116 WP_017900384.1 serine hydrolase -
H7R75_RS12435 2562033..2562377 + 345 WP_017900383.1 hypothetical protein -
H7R75_RS12440 2562406..2562939 + 534 WP_004205916.1 hypothetical protein -
H7R75_RS12445 2562942..2563148 + 207 WP_004205917.1 helix-turn-helix transcriptional regulator -
H7R75_RS12450 2563290..2564582 + 1293 WP_017900382.1 glycoside hydrolase family 10 protein -
H7R75_RS12455 2564599..2565921 - 1323 WP_017900381.1 type II toxin-antitoxin system HipA family toxin Toxin
H7R75_RS12460 2565921..2566187 - 267 WP_004205921.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
H7R75_RS12465 2566470..2566796 - 327 WP_017900379.1 hydroxyisourate hydrolase -
H7R75_RS12470 2566793..2567293 - 501 WP_017900378.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
H7R75_RS12475 2567271..2568650 - 1380 WP_017900377.1 purine permease -
H7R75_RS12480 2568996..2570150 + 1155 WP_017900376.1 FAD-dependent urate hydroxylase HpxO -
H7R75_RS12485 2570131..2571054 - 924 WP_004205929.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49041.33 Da        Isoelectric Point: 8.6091

>T34899 WP_017900381.1 NZ_AP022183:c2565921-2564599 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARRTLPSDFSAHVWRAITENMLKLHARLQQGLQAG

Download         Length: 1323 bp

>T34899 NZ_AP022183:c2565921-2564599 [Klebsiella quasipneumoniae]
ATGGCGACGCTCACCACCTGGATGAACAATGCGCGCGTGGGAACCTTAACCCGCCAGGCCAACGGGGCGCACAGTTTCCG
CTATGATGAGGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCGCTGCCGCTGCAGTATGGCAATATCACCG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGAGCGGATCGTCAGGCGCTATCAG
GCGCGTTCGAAACAGCCGTTCGATCTGCTGGCCGAGGTCGGGCGGGACAGCGTAGGGGCGGTGACGCTGCTGCCGCCGGG
GGAAGAGGCGCATCTTGCCGCGTTGCGCTGGCAGACGCTGGATGAGGCGCAGCTGACCGCTTTGCTGACCGCCTACCAGT
CGGATATTCCTCTCGGAATGGTGACCGGCCAGGACGATTTTCGTATCTCGGTGGCCGGCGCTCAGGAGAAAACCGCGCTG
CTGCGAATGGGCGAGCACTGGTGTATTCCGCAGGGCACCACCCCGACCACCCATATCATTAAACTGCCTATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAACGAATATTTGTGCCTGGCGCTGGCCAGGGCGTTGG
GCCTGGCGGTGCCGGAGGCGGAGATTATCAACACGCCGCGGATCCGTGCGCTGGCGGTGACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGGCGCGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCATTCGGCATACCGTCGTCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGTTCCAGTGAGGCCCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTGTTCCAGTGGCTGACCGGGGCAACGGACGGGCATGCGAAGAACTTCTCGCTCTTTTTGCTG
CCCGGCGGCAGCTACCGGCTCACGCCGTTCTACGACATTATTTCGGCATTTCCGGTGCTGGGCGGGACGGGACTGCATCT
GCGCGACCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGGAAAACGGAGATTAACGCTATCTATCCGCGTCATT
TTCTGGCGACCGCCAAAGCGGTTAACTTCCCCCGGGAGCAGATGCTGGCGATCCTGGGCGAGTTTGCCGACCGCGTGCCG
CAGGCCATCGAAAGCGCCCGCCGGACGCTGCCGTCGGACTTTTCCGCCCACGTCTGGCGGGCCATCACGGAGAACATGCT
GAAACTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGGGATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9940.38 Da        Isoelectric Point: 7.1997

>AT34899 WP_004205921.1 NZ_AP022183:c2566187-2565921 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW

Download         Length: 267 bp

>AT34899 NZ_AP022183:c2566187-2565921 [Klebsiella quasipneumoniae]
ATGAATTCCCCGCAGATATACAGTCCGGTTCAGCTGGCCAATTACCTGAAACTGCTGCGCCAGCAAAATCACTGGACTCA
GGAGGCGCTGGCCAGCCGGATCGGCATTAAACAGGCGACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACCCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACCCTGAACGCCAAACCGGCAGAGACGGCGATGATTCCC
GATAACACCACGGATCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246AZS4

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MFC9

References