Detailed information of TA system TA034886

Bioinformatically predicted

Overview

TA module

• Type: III
• Classification (family/domain): toxIN/ToxN(toxin)
• Location: 3050..3715
• Replicon: plasmid pWP7-S17-ESBL-04_4
• Accession: NZ_AP022181
• Organism: Escherichia coli strain WP7-S17-ESBL-04

Toxin (Protein)

• Gene name: toxN
• Uniprot ID: -
• Locus tag: H7R11_RS23920
• Protein ID: WP_126896380.1
• Coordinates: 3050..3565 (-)
• Length: 172 a.a.

Antitoxin (RNA)

Gene name	toxI
Locus tag	-
Coordinates	3568..3715 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R11_RS23895	101..295	-	195	WP_001041618.1	Rop family plasmid primer RNA-binding protein	-
H7R11_RS23900	579..902	+	324	WP_000166966.1	hypothetical protein	-
H7R11_RS23905	1136..1417	-	282	WP_071830593.1	hypothetical protein	-
H7R11_RS23910	1427..1684	-	258	WP_001125013.1	hypothetical protein	-
H7R11_RS23915	2229..2939	+	711	WP_024165718.1	hypothetical protein	-
H7R11_RS23920	3050..3565	-	516	WP_126896380.1	type III toxin-antitoxin system ToxN/AbiQ family toxin	Toxin
-	3568..3715	-	148	NuclAT_0	-	Antitoxin
-	3568..3715	-	148	NuclAT_0	-	Antitoxin
-	3568..3715	-	148	NuclAT_0	-	Antitoxin
-	3568..3715	-	148	NuclAT_0	-	Antitoxin
-	3618..3675	-	58	NuclAT_5	-	-
-	3618..3675	-	58	NuclAT_5	-	-
-	3618..3675	-	58	NuclAT_5	-	-
-	3618..3675	-	58	NuclAT_5	-	-
-	3618..3711	-	94	NuclAT_2	-	-
-	3618..3711	-	94	NuclAT_2	-	-
-	3618..3711	-	94	NuclAT_2	-	-
-	3618..3711	-	94	NuclAT_2	-	-
-	3618..3712	-	95	NuclAT_1	-	-
-	3618..3712	-	95	NuclAT_1	-	-
-	3618..3712	-	95	NuclAT_1	-	-
-	3618..3712	-	95	NuclAT_1	-	-
-	3618..3715	-	98	NuclAT_3	-	-
-	3618..3715	-	98	NuclAT_3	-	-
-	3618..3715	-	98	NuclAT_3	-	-
-	3618..3715	-	98	NuclAT_3	-	-
-	3654..3715	-	62	NuclAT_4	-	-
-	3654..3715	-	62	NuclAT_4	-	-
-	3654..3715	-	62	NuclAT_4	-	-
-	3654..3715	-	62	NuclAT_4	-	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..4491	4491

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• ToxN/AbiQ toxin (1-160)

Sequences

Toxin

Protein

• Length: 172 a.a.
• Molecular weight: 19793.74 Da
• Isoelectric Point: 5.6847

>T34886 WP_126896380.1 NZ_AP022181:c3565-3050 [Escherichia coli]
MKFYTISSSYIKYLKDFDDKVPNSEDPTYNNPKAFIGIVLEIEGHKYLAPLTSPKAWHANIKESSPAFFKLHENGVPDNQ
LGLINLKFMIPIIEAEVSLLDLDSMPDTPYKRMLYKQLQFIRVNEDKISEKSKLLRNLALQGRMQGTCDFSVLEEKYQHF
GKKPEDMEIDD

Nucleotide

• Length: 516 bp

>T34886 NZ_AP022181:c3565-3050 [Escherichia coli]
ATGAAATTTTACACAATATCAAGCAGTTACATAAAATACCTGAAGGACTTTGATGACAAAGTTCCCAATAGCGAAGATCC
TACATACAACAATCCTAAGGCTTTCATTGGCATAGTACTAGAGATTGAAGGACATAAATATTTAGCACCTTTAACGTCGC
CAAAAGCATGGCATGCTAATATAAAAGAGTCATCACCCGCCTTCTTCAAACTTCATGAAAACGGTGTCCCTGACAATCAG
CTTGGATTGATTAATCTGAAATTTATGATTCCAATAATCGAAGCTGAAGTGTCTTTACTTGATCTGGATAGCATGCCTGA
TACGCCTTACAAAAGAATGCTATATAAACAGTTACAATTTATTCGTGTAAATGAAGATAAAATATCTGAAAAATCAAAAC
TATTAAGAAACCTTGCCTTGCAAGGCAGAATGCAAGGAACATGCGACTTTTCCGTATTAGAAGAAAAATATCAACATTTC
GGTAAAAAACCTGAAGACATGGAAATAGACGATTAA

Antitoxin

Nucleotide

• Length: 148 bp

>AT34886 NZ_AP022181:c3715-3568 [Escherichia coli]
TTCAAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTTAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTTAGGT
CATTTACTACCTTAAAGTAATAAAGTAAAAAAGGCGACTATACACAGTCGCCTTTTTTATGAGAAAAA

Structures

Antitoxin