Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2940927..2941398 | Replicon | chromosome |
| Accession | NZ_AP022171 | ||
| Organism | Escherichia coli strain WP5-S18-ESBL-09 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | H7R27_RS14245 | Protein ID | WP_001303511.1 |
| Coordinates | 2941120..2941398 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | H7R27_RS14240 | Protein ID | WP_001302048.1 |
| Coordinates | 2940927..2941118 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H7R27_RS14170 | 2935994..2936161 | - | 168 | WP_000207997.1 | hypothetical protein | - |
| H7R27_RS14175 | 2936172..2936435 | - | 264 | WP_000224216.1 | hypothetical protein | - |
| H7R27_RS14180 | 2936437..2936655 | - | 219 | WP_001142588.1 | DUF4014 family protein | - |
| H7R27_RS14185 | 2936657..2936872 | - | 216 | WP_000510387.1 | hypothetical protein | - |
| H7R27_RS14190 | 2936873..2937232 | - | 360 | WP_001289986.1 | hypothetical protein | - |
| H7R27_RS14195 | 2937229..2937405 | - | 177 | WP_021534704.1 | hypothetical protein | - |
| H7R27_RS14200 | 2937398..2937580 | - | 183 | WP_001224665.1 | hypothetical protein | - |
| H7R27_RS14205 | 2937709..2938020 | - | 312 | WP_021534703.1 | hypothetical protein | - |
| H7R27_RS14210 | 2938013..2938267 | - | 255 | WP_000004322.1 | hypothetical protein | - |
| H7R27_RS14215 | 2938264..2938686 | - | 423 | WP_021534702.1 | DUF977 family protein | - |
| H7R27_RS14220 | 2938727..2939689 | - | 963 | WP_000095673.1 | helix-turn-helix domain-containing protein | - |
| H7R27_RS14225 | 2939712..2940137 | - | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| H7R27_RS14230 | 2940134..2940436 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| H7R27_RS14235 | 2940535..2940906 | + | 372 | WP_001169687.1 | hypothetical protein | - |
| H7R27_RS14240 | 2940927..2941118 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| H7R27_RS14245 | 2941120..2941398 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| H7R27_RS14250 | 2941690..2941842 | + | 153 | WP_000380313.1 | DUF1391 family protein | - |
| H7R27_RS14255 | 2941854..2942192 | + | 339 | WP_000394541.1 | hypothetical protein | - |
| H7R27_RS14260 | 2942181..2942447 | - | 267 | WP_012601410.1 | hypothetical protein | - |
| H7R27_RS14265 | 2942942..2943130 | + | 189 | WP_000449172.1 | cell division inhibitor | - |
| H7R27_RS14270 | 2943127..2943315 | + | 189 | WP_000199480.1 | DUF1482 family protein | - |
| H7R27_RS14275 | 2943411..2945882 | + | 2472 | WP_032284123.1 | exonuclease | - |
| H7R27_RS14280 | 2945944..2946213 | + | 270 | WP_000003742.1 | excisionase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2892434..2954468 | 62034 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T34803 WP_001303511.1 NZ_AP022171:2941120-2941398 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T34803 NZ_AP022171:2941120-2941398 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT34803 WP_001302048.1 NZ_AP022171:2940927-2941118 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT34803 NZ_AP022171:2940927-2941118 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGTAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGTAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|