Detailed information of TA system TA034790

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 812480..813314
• Replicon: chromosome
• Accession: NZ_AP022171
• Organism: Escherichia coli strain WP5-S18-ESBL-09

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: H7R27_RS03895
• Protein ID: WP_001546109.1
• Coordinates: 812480..812857 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A7I0L0C8
• Locus tag: H7R27_RS03900
• Protein ID: WP_001546108.1
• Coordinates: 812934..813314 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R27_RS03865	808874..809029	-	156	WP_000729639.1	hypothetical protein	-
H7R27_RS03870	809461..810395	-	935	Protein_760	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
H7R27_RS03875	810388..810783	-	396	WP_000208383.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
H7R27_RS03880	810852..811697	-	846	WP_001280441.1	DUF4942 domain-containing protein	-
H7R27_RS03885	811782..811979	-	198	WP_000839260.1	DUF957 domain-containing protein	-
H7R27_RS03890	811996..812483	-	488	Protein_764	hypothetical protein	-
H7R27_RS03895	812480..812857	-	378	WP_001546109.1	TA system toxin CbtA family protein	Toxin
H7R27_RS03900	812934..813314	-	381	WP_001546108.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
H7R27_RS03905	813364..814008	-	645	WP_000086755.1	hypothetical protein	-
H7R27_RS03910	814027..814248	-	222	WP_000692345.1	DUF987 domain-containing protein	-
H7R27_RS03915	814317..814793	-	477	WP_001424026.1	RadC family protein	-
H7R27_RS03920	814809..815294	-	486	WP_000849588.1	antirestriction protein	-
H7R27_RS03925	815349..816167	-	819	WP_001234620.1	DUF945 domain-containing protein	-
H7R27_RS03930	816267..816500	-	234	WP_001119729.1	DUF905 family protein	-
H7R27_RS03935	816579..817034	-	456	WP_001545736.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13986.00 Da
• Isoelectric Point: 8.5190

>T34790 WP_001546109.1 NZ_AP022171:c812857-812480 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYKMVNNITQGKHPEAKR

Nucleotide

• Length: 378 bp

>T34790 NZ_AP022171:c812857-812480 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAAAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13997.78 Da
• Isoelectric Point: 5.0823

>AT34790 WP_001546108.1 NZ_AP022171:c813314-812934 [Escherichia coli]
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFNNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT34790 NZ_AP022171:c813314-812934 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAACAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Structures

Antitoxin

• AlphaFold DB: A0A7I0L0C8