Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2697862..2698500 Replicon chromosome
Accession NZ_AP022161
Organism Escherichia coli strain WP5-S18-ESBL-08

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag H7R36_RS12815 Protein ID WP_000813794.1
Coordinates 2698324..2698500 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H7R36_RS12810 Protein ID WP_001270286.1
Coordinates 2697862..2698278 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R36_RS12790 2693014..2693955 - 942 WP_022645667.1 ABC transporter permease -
H7R36_RS12795 2693956..2694969 - 1014 WP_022645666.1 ABC transporter ATP-binding protein -
H7R36_RS12800 2694987..2696132 - 1146 WP_000047466.1 ABC transporter substrate-binding protein -
H7R36_RS12805 2696377..2697783 - 1407 WP_022645665.1 PLP-dependent aminotransferase family protein -
H7R36_RS12810 2697862..2698278 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
H7R36_RS12815 2698324..2698500 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
H7R36_RS12820 2698722..2698952 + 231 WP_000491567.1 DUF2554 family protein -
H7R36_RS12825 2699044..2701005 - 1962 WP_023909195.1 23S rRNA 5-hydroxycytidine C2501 synthase -
H7R36_RS12830 2701078..2701614 - 537 WP_000429148.1 DNA-binding transcriptional regulator SutR -
H7R36_RS12835 2701667..2702878 + 1212 WP_071788120.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T34761 WP_000813794.1 NZ_AP022161:c2698500-2698324 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T34761 NZ_AP022161:c2698500-2698324 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTGAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT34761 WP_001270286.1 NZ_AP022161:c2698278-2697862 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT34761 NZ_AP022161:c2698278-2697862 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAACAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References