Detailed information of TA system TA034739

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4356951..4357771
• Replicon: chromosome
• Accession: NZ_AP022159
• Organism: Escherichia coli strain WP5-S18-ESBL-07

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A0V9MKL8
• Locus tag: H7R21_RS20790
• Protein ID: WP_001550554.1
• Coordinates: 4356951..4357208 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: H7R21_RS20795
• Protein ID: WP_001519303.1
• Coordinates: 4357220..4357771 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R21_RS20770	4352237..4353343	+	1107	WP_001519308.1	N-acetylneuraminate epimerase	-
H7R21_RS20775	4353408..4354388	+	981	WP_001519307.1	transposase	-
H7R21_RS20780	4354971..4356212	-	1242	Protein_4066	DNA helicase	-
H7R21_RS20785	4356275..4356574	+	300	WP_001519304.1	GNAT family N-acetyltransferase	-
H7R21_RS20790	4356951..4357208	+	258	WP_001550554.1	hypothetical protein	Toxin
H7R21_RS20795	4357220..4357771	+	552	WP_001519303.1	N-acetyltransferase	Antitoxin
H7R21_RS20800	4357823..4357984	+	162	WP_001519302.1	hypothetical protein	-
H7R21_RS20805	4358021..4358569	+	549	WP_001519301.1	hypothetical protein	-
H7R21_RS20810	4358696..4358956	+	261	WP_000084876.1	hypothetical protein	-
H7R21_RS24810	4358994..4359110	+	117	Protein_4073	VOC family protein	-
H7R21_RS20815	4359355..4360476	+	1122	WP_000010833.1	M42 family metallopeptidase	-
H7R21_RS20820	4360473..4360751	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
H7R21_RS20825	4360763..4362076	+	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB	4349435..4429134	79699

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9744.33 Da
• Isoelectric Point: 11.0090

>T34739 WP_001550554.1 NZ_AP022159:4356951-4357208 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKPVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T34739 NZ_AP022159:4356951-4357208 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGCCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT34739 WP_001519303.1 NZ_AP022159:4357220-4357771 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT34739 NZ_AP022159:4357220-4357771 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCGACCTTCAAAGGAGAAATGGATTCACCGCTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: A0A0V9MKL8