Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 77612..78207 Replicon plasmid pWP5-S18-ESBL-05_1
Accession NZ_AP022143
Organism Klebsiella quasipneumoniae strain WP5-S18-ESBL-05

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag H7R80_RS26285 Protein ID WP_182940150.1
Coordinates 77830..78207 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag H7R80_RS26280 Protein ID WP_182940149.1
Coordinates 77612..77833 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R80_RS26255 73901..74323 + 423 WP_182940162.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
H7R80_RS26260 74323..75594 + 1272 WP_182940145.1 translesion error-prone DNA polymerase V subunit UmuC -
H7R80_RS26265 75688..75975 + 288 WP_182940146.1 DUF1778 domain-containing protein -
H7R80_RS26270 75963..76448 + 486 WP_182940147.1 GNAT family N-acetyltransferase -
H7R80_RS26275 76539..76799 - 261 WP_182940148.1 hypothetical protein -
H7R80_RS26280 77612..77833 + 222 WP_182940149.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
H7R80_RS26285 77830..78207 + 378 WP_182940150.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
H7R80_RS26290 78682..78942 + 261 WP_182940151.1 hypothetical protein -
H7R80_RS26295 79021..79992 + 972 WP_182940152.1 Hok/Gef family protein -
H7R80_RS26300 80184..80561 - 378 WP_182940153.1 phosphonate ABC transporter substrate-binding protein -
H7R80_RS26305 82378..82665 + 288 WP_182940154.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaCTX-M-62 / aadA2 / qacE / sul1 - 1..215703 215703
- flank IS/Tn - - 72575..73795 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13795.95 Da        Isoelectric Point: 6.2182

>T34708 WP_182940150.1 NZ_AP022143:77830-78207 [Klebsiella quasipneumoniae]
MKWVSAKEVIGIHDRLLALLAGVPGMPDPDRAEAIIYRVQNRHFYESVDDLFELAATYLVAIARGHIFNDGNKRTALAVS
MLFLRRNGIVLAVTGSVLDDLTVDAATGDLLVDQVAQVLRKQCYN

Download         Length: 378 bp

>T34708 NZ_AP022143:77830-78207 [Klebsiella quasipneumoniae]
ATGAAGTGGGTTAGCGCTAAAGAGGTTATCGGCATCCACGACCGCCTGTTAGCGTTGCTGGCGGGGGTGCCGGGAATGCC
AGATCCGGACCGTGCTGAAGCCATTATATACCGGGTTCAAAATCGACATTTCTATGAATCAGTTGATGATCTCTTTGAGC
TGGCTGCAACTTATCTGGTGGCTATCGCTCGTGGGCATATCTTCAACGACGGGAATAAACGTACAGCTCTCGCGGTCTCG
ATGTTGTTTCTTCGACGCAATGGGATCGTTCTGGCTGTTACCGGGTCAGTACTGGACGATTTGACGGTTGACGCGGCCAC
AGGCGATTTGCTGGTGGACCAGGTGGCCCAAGTGCTACGTAAGCAATGCTACAACTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8278.16 Da        Isoelectric Point: 4.4000

>AT34708 WP_182940149.1 NZ_AP022143:77612-77833 [Klebsiella quasipneumoniae]
MKSYTATEARQSISEVMDIASSGEPVEITRRDGTSNVLISREEFDAWQNQKLDAEFADIMQHYGKPIEALTNR

Download         Length: 222 bp

>AT34708 NZ_AP022143:77612-77833 [Klebsiella quasipneumoniae]
ATGAAATCATATACTGCAACCGAAGCCCGGCAATCGATCTCCGAAGTGATGGACATCGCCTCCTCCGGGGAACCTGTGGA
GATCACCCGTCGTGATGGAACGTCAAATGTCCTGATTAGCCGGGAAGAGTTCGACGCCTGGCAAAATCAGAAGCTGGATG
CCGAATTTGCGGACATCATGCAGCATTATGGCAAACCAATTGAAGCGTTGACCAACCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References