Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 75688..76448 Replicon plasmid pWP5-S18-ESBL-05_1
Accession NZ_AP022143
Organism Klebsiella quasipneumoniae strain WP5-S18-ESBL-05

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag H7R80_RS26270 Protein ID WP_182940147.1
Coordinates 75963..76448 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag H7R80_RS26265 Protein ID WP_182940146.1
Coordinates 75688..75975 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R80_RS26235 70784..71124 + 341 Protein_85 hypothetical protein -
H7R80_RS26240 71152..71517 + 366 WP_182940143.1 hypothetical protein -
H7R80_RS26245 71860..72273 - 414 WP_182940144.1 hypothetical protein -
H7R80_RS26250 72575..73795 - 1221 WP_000343760.1 ISL3-like element ISKox3 family transposase -
H7R80_RS26255 73901..74323 + 423 WP_182940162.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
H7R80_RS26260 74323..75594 + 1272 WP_182940145.1 translesion error-prone DNA polymerase V subunit UmuC -
H7R80_RS26265 75688..75975 + 288 WP_182940146.1 DUF1778 domain-containing protein Antitoxin
H7R80_RS26270 75963..76448 + 486 WP_182940147.1 GNAT family N-acetyltransferase Toxin
H7R80_RS26275 76539..76799 - 261 WP_182940148.1 hypothetical protein -
H7R80_RS26280 77612..77833 + 222 WP_182940149.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
H7R80_RS26285 77830..78207 + 378 WP_182940150.1 type II toxin-antitoxin system death-on-curing family toxin -
H7R80_RS26290 78682..78942 + 261 WP_182940151.1 hypothetical protein -
H7R80_RS26295 79021..79992 + 972 WP_182940152.1 Hok/Gef family protein -
H7R80_RS26300 80184..80561 - 378 WP_182940153.1 phosphonate ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaCTX-M-62 / aadA2 / qacE / sul1 - 1..215703 215703
- flank IS/Tn - - 72575..73795 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17795.67 Da        Isoelectric Point: 10.3370

>T34707 WP_182940147.1 NZ_AP022143:75963-76448 [Klebsiella quasipneumoniae]
VGRVTTPEPLSSHHQLAEFVSGEAVLDDWLKMRGLKNQAIGASRTFVVCRKETKQVVGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVQALTEKAKSFYVHHSFRPSQTQPMTLFLKLP
Q

Download         Length: 486 bp

>T34707 NZ_AP022143:75963-76448 [Klebsiella quasipneumoniae]
GTGGGAAGAGTAACCACACCAGAGCCTTTATCCAGTCACCATCAACTGGCGGAGTTCGTTAGCGGTGAAGCGGTACTCGA
TGACTGGTTAAAAATGAGAGGTCTTAAAAATCAGGCTATAGGTGCTTCGCGAACATTCGTAGTTTGCAGGAAGGAAACGA
AACAGGTCGTCGGCTTTTATTCTCTTGCTACGGGTAGCGTTAACCATACAGAAGCTACAGGCAGTCTCCGGCGTAACATG
CCTGACCCCATTCCCGTCATCATACTTGCCCGTCTGGCTGTCGATCTCTCATTCCGAGGGAAAGGGCTTGGTGCTGATTT
ACTGCATGACGCGGTACTGCGTTGCTATCGGGTAGCAGAAAACATCGGTGTCCGCGCAATCATGGTCCAGGCGCTGACAG
AGAAAGCCAAAAGTTTCTATGTGCACCATAGTTTCAGGCCCTCACAAACCCAGCCTATGACATTGTTCCTTAAACTCCCT
CAGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11013.64 Da        Isoelectric Point: 4.6437

>AT34707 WP_182940146.1 NZ_AP022143:75688-75975 [Klebsiella quasipneumoniae]
MLYKGFPMKSDVQLNLRAKESQRALIDTAANILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVVDD
PVVNKLLARKPQWEE

Download         Length: 288 bp

>AT34707 NZ_AP022143:75688-75975 [Klebsiella quasipneumoniae]
ATGCTATACAAGGGATTCCCGATGAAATCAGATGTTCAACTTAACCTAAGAGCCAAAGAATCGCAGCGAGCGCTCATTGA
TACCGCTGCGAACATCCTCCACAAATCGCGTACAGACTTCATTCTGGAAATGGCCTGTCAGGCAGCAGAGAATGTAATAC
TCGATCGCCGTGTCTTTAATTTTAACGATGAGCAATATGCAGAGTTCATCGACATGCTTGATGCTCCGGTTGTGGATGAC
CCTGTGGTTAACAAGCTGCTGGCAAGGAAACCACAGTGGGAAGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References