Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1559323..1559942 Replicon chromosome
Accession NZ_AP022142
Organism Klebsiella quasipneumoniae strain WP5-S18-ESBL-05

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag H7R80_RS07555 Protein ID WP_002892050.1
Coordinates 1559323..1559541 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag H7R80_RS07560 Protein ID WP_002892066.1
Coordinates 1559568..1559942 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R80_RS07520 1555366..1555629 + 264 WP_004204754.1 type B 50S ribosomal protein L31 -
H7R80_RS07525 1555629..1555769 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
H7R80_RS07530 1555766..1556464 - 699 WP_101862457.1 GNAT family N-acetyltransferase -
H7R80_RS07535 1556565..1558022 + 1458 WP_101862458.1 PLP-dependent aminotransferase family protein -
H7R80_RS07540 1557991..1558461 - 471 WP_023288642.1 YlaC family protein -
H7R80_RS07545 1558495..1558626 + 132 WP_032428629.1 hypothetical protein -
H7R80_RS07550 1558598..1559164 - 567 WP_023288643.1 maltose O-acetyltransferase -
H7R80_RS07555 1559323..1559541 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
H7R80_RS07560 1559568..1559942 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
H7R80_RS07565 1560426..1563572 - 3147 WP_023288644.1 multidrug efflux RND transporter permease subunit -
H7R80_RS07570 1563595..1564788 - 1194 WP_023288645.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T34694 WP_002892050.1 NZ_AP022142:c1559541-1559323 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T34694 NZ_AP022142:c1559541-1559323 [Klebsiella quasipneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGCCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAACAAATATGAACTTTCTGATAATGAGCTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACGTCCGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT34694 WP_002892066.1 NZ_AP022142:c1559942-1559568 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT34694 NZ_AP022142:c1559942-1559568 [Klebsiella quasipneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCACAACTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACATCGGCTGTCAATCTCCAGTTAAATGAACTGATCGAGC
ACATTGCCACGTTCGCCCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGATACATTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGGTT
ATTTCGTTGTTTTGTCAACGCCAGCCGGGAAAATCCGGCCAGTCTTTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References