Detailed information of TA system TA034693

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 872805..873276
• Replicon: chromosome
• Accession: NZ_AP022142
• Organism: Klebsiella quasipneumoniae strain WP5-S18-ESBL-05

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H7R80_RS04325
• Protein ID: WP_023291758.1
• Coordinates: 873037..873276 (+)
• Length: 80 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1C1EW86
• Locus tag: H7R80_RS04320
• Protein ID: WP_023291757.1
• Coordinates: 872805..873047 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R80_RS04305	868836..869576	+	741	WP_101862400.1	KDGP aldolase family protein	-
H7R80_RS04310	869643..870794	+	1152	WP_032454657.1	lactonase family protein	-
H7R80_RS04315	870817..872727	+	1911	WP_032454658.1	BglG family transcription antiterminator	-
H7R80_RS04320	872805..873047	+	243	WP_023291757.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
H7R80_RS04325	873037..873276	+	240	WP_023291758.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H7R80_RS04330	873325..873789	-	465	WP_012969085.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
H7R80_RS04335	874185..876323	-	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-79)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-70)

Sequences

Toxin

Protein

• Length: 80 a.a.
• Molecular weight: 9162.72 Da
• Isoelectric Point: 10.1315

>T34693 WP_023291758.1 NZ_AP022142:873037-873276 [Klebsiella quasipneumoniae]
MTYELAFDPRAWREWQKLGETIKKQFKNKLQQVVQNPRIASASLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIG

Nucleotide

• Length: 240 bp

>T34693 NZ_AP022142:873037-873276 [Klebsiella quasipneumoniae]
ATGACCTATGAACTGGCGTTTGATCCGCGTGCCTGGCGCGAATGGCAGAAGCTTGGCGAGACGATCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGGTTGTGCAGAATCCGCGAATTGCATCGGCCAGTCTGAGTGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGGGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9119.58 Da
• Isoelectric Point: 4.8146

>AT34693 WP_023291757.1 NZ_AP022142:872805-873047 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDSEAALLRTVRERLENPQPEVKVSLDDL

Nucleotide

• Length: 243 bp

>AT34693 NZ_AP022142:872805-873047 [Klebsiella quasipneumoniae]
ATGGCCACGCTCAACGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTGCGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCAGTGAAAAGTATGACTATCAGCGATA
GCGAAGCGGCATTATTACGCACCGTCCGCGAGCGGCTGGAAAACCCGCAGCCGGAGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A1C1EW86