Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 7165..7808 Replicon plasmid pWP5-S18-ESBL-02_1
Accession NZ_AP022140
Organism Klebsiella pneumoniae strain WP5-S18-ESBL-02

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag H7R18_RS25470 Protein ID WP_016236302.1
Coordinates 7165..7581 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag H7R18_RS25475 Protein ID WP_073611364.1
Coordinates 7578..7808 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R18_RS25435 2535..2870 - 336 WP_000046891.1 thermonuclease family protein -
H7R18_RS25440 3113..3676 + 564 WP_001515734.1 transposase -
H7R18_RS25445 3741..4115 + 375 WP_001348195.1 cupin domain-containing protein -
H7R18_RS25450 4139..4702 + 564 WP_001097412.1 chlorite dismutase family protein -
H7R18_RS25455 4953..6050 - 1098 Protein_8 IS66 family transposase -
H7R18_RS25460 6104..6808 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
H7R18_RS25465 6855..7091 - 237 WP_001348075.1 AAA family ATPase -
H7R18_RS25470 7165..7581 - 417 WP_016236302.1 type II toxin-antitoxin system VapC family toxin Toxin
H7R18_RS25475 7578..7808 - 231 WP_073611364.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H7R18_RS25480 8362..9282 + 921 WP_048235060.1 hypothetical protein -
H7R18_RS25485 9279..10088 + 810 WP_053059919.1 hypothetical protein -
H7R18_RS25490 10450..10797 + 348 WP_074405026.1 hypothetical protein -
H7R18_RS25495 10835..11617 + 783 WP_182915613.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..85044 85044


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15091.55 Da        Isoelectric Point: 7.1084

>T34692 WP_016236302.1 NZ_AP022140:c7581-7165 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLELAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

>T34692 NZ_AP022140:c7581-7165 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCTGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8722.77 Da        Isoelectric Point: 4.4432

>AT34692 WP_073611364.1 NZ_AP022140:c7808-7578 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT34692 NZ_AP022140:c7808-7578 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATTCGGCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References