Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4196032..4196689 Replicon chromosome
Accession NZ_AP022126
Organism Enterobacter cloacae strain WP5-S18-CRE-02

Toxin (Protein)


Gene name cptA Uniprot ID A0A2W0G6Z0
Locus tag H7R61_RS20430 Protein ID WP_014885136.1
Coordinates 4196032..4196442 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag H7R61_RS20435 Protein ID WP_010435322.1
Coordinates 4196423..4196689 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R61_RS20410 4192026..4193759 - 1734 WP_023331239.1 single-stranded-DNA-specific exonuclease RecJ -
H7R61_RS20415 4193765..4194478 - 714 WP_014885133.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H7R61_RS20420 4194507..4195403 - 897 WP_023337727.1 site-specific tyrosine recombinase XerD -
H7R61_RS20425 4195505..4196026 + 522 WP_014885135.1 flavodoxin FldB -
H7R61_RS20430 4196032..4196442 - 411 WP_014885136.1 protein YgfX Toxin
H7R61_RS20435 4196423..4196689 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
H7R61_RS20440 4196984..4197964 + 981 WP_023337728.1 tRNA-modifying protein YgfZ -
H7R61_RS20445 4198049..4198708 - 660 WP_023331242.1 hemolysin III family protein -
H7R61_RS20450 4198974..4199705 + 732 WP_032645400.1 MurR/RpiR family transcriptional regulator -
H7R61_RS20455 4199822..4201255 + 1434 WP_057056061.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.04 Da        Isoelectric Point: 10.7510

>T34668 WP_014885136.1 NZ_AP022126:c4196442-4196032 [Enterobacter cloacae]
VVLWQSDLRVSWRSQWMSLMLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNSGMMLRLRNVDGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T34668 NZ_AP022126:c4196442-4196032 [Enterobacter cloacae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTAATGCTCCACGGCCTGGTTGCGGC
CATCGTGTTACTCATGCCATGGCCCCTGAGCTATACGCCGCTGTGGCTGCTGTTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCTCGTCAGGGTGAGATCAAGTTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTGGGCATGCCATGGATGCTCAACTCCGGCATGATGTTACGGTTACGCAATGTGGACGGCGGGCGTTG
CCAGCACCTGTGGCTGGCGGCTGACAGTATGGATGCCTCAGAATGGCGAGATCTGCGCCGGATGTTGTTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT34668 WP_010435322.1 NZ_AP022126:c4196689-4196423 [Enterobacter cloacae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT34668 NZ_AP022126:c4196689-4196423 [Enterobacter cloacae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCATGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGGCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCAGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G6Z0

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References