Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 1761951..1762864 | Replicon | chromosome |
| Accession | NZ_AP022126 | ||
| Organism | Enterobacter cloacae strain WP5-S18-CRE-02 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A2J0PLX5 |
| Locus tag | H7R61_RS08525 | Protein ID | WP_023337016.1 |
| Coordinates | 1761951..1762424 (-) | Length | 158 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J0PMR8 |
| Locus tag | H7R61_RS08530 | Protein ID | WP_023337017.1 |
| Coordinates | 1762421..1762864 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H7R61_RS08505 | 1758114..1759421 | + | 1308 | WP_182945057.1 | type I-F CRISPR-associated protein Csy1 | - |
| H7R61_RS08510 | 1759418..1760353 | + | 936 | WP_023337013.1 | type I-F CRISPR-associated protein Csy2 | - |
| H7R61_RS08515 | 1760367..1761365 | + | 999 | WP_023337014.1 | type I-F CRISPR-associated protein Csy3 | - |
| H7R61_RS08520 | 1761375..1761929 | + | 555 | WP_023337015.1 | type I-F CRISPR-associated endoribonuclease Cas6/Csy4 | - |
| H7R61_RS08525 | 1761951..1762424 | - | 474 | WP_023337016.1 | RES domain-containing protein | Toxin |
| H7R61_RS08530 | 1762421..1762864 | - | 444 | WP_023337017.1 | DUF2384 domain-containing protein | Antitoxin |
| H7R61_RS08535 | 1764621..1764839 | - | 219 | WP_002211347.1 | translation initiation factor IF-1 | - |
| H7R61_RS08540 | 1765124..1765828 | - | 705 | WP_023337019.1 | leucyl/phenylalanyl-tRNA--protein transferase | - |
| H7R61_RS08545 | 1765874..1767595 | - | 1722 | WP_014883200.1 | cysteine/glutathione ABC transporter ATP-binding protein/permease CydC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 158 a.a. Molecular weight: 17570.82 Da Isoelectric Point: 5.0700
>T34659 WP_023337016.1 NZ_AP022126:c1762424-1761951 [Enterobacter cloacae]
MIFYRLVTGRYASEAWSGSGANQYGGRWNHKGHPAVYVSTSISLASLEILVHVRKDTVLNQYQLFSIDIPDDQIDYLDKA
WLPEDWQENPAPVSTMDLGTGWLQANSALALILPSCIIPYENNAILNPLHPSFHTALNSVQQLPFNFDTRLAEKTAP
MIFYRLVTGRYASEAWSGSGANQYGGRWNHKGHPAVYVSTSISLASLEILVHVRKDTVLNQYQLFSIDIPDDQIDYLDKA
WLPEDWQENPAPVSTMDLGTGWLQANSALALILPSCIIPYENNAILNPLHPSFHTALNSVQQLPFNFDTRLAEKTAP
Download Length: 474 bp
>T34659 NZ_AP022126:c1762424-1761951 [Enterobacter cloacae]
ATGATTTTTTATCGTCTGGTGACAGGGCGCTATGCCAGCGAAGCGTGGAGCGGAAGTGGTGCAAACCAGTATGGCGGGCG
GTGGAATCATAAAGGCCATCCAGCTGTGTATGTGTCCACCTCCATTTCACTGGCCTCACTGGAGATTTTGGTGCACGTTC
GAAAAGATACTGTACTGAATCAGTACCAGCTTTTCAGCATTGATATCCCGGATGACCAGATTGATTACCTGGATAAAGCG
TGGCTCCCCGAGGACTGGCAGGAAAATCCGGCCCCCGTATCAACGATGGATCTGGGAACCGGTTGGTTGCAGGCTAACAG
CGCCCTCGCACTCATCTTACCCTCCTGCATCATTCCTTATGAAAACAATGCCATCCTTAACCCCTTACATCCGTCCTTCC
ACACGGCGCTCAATTCAGTTCAGCAACTGCCCTTTAATTTTGATACCCGCCTGGCTGAAAAAACCGCACCCTGA
ATGATTTTTTATCGTCTGGTGACAGGGCGCTATGCCAGCGAAGCGTGGAGCGGAAGTGGTGCAAACCAGTATGGCGGGCG
GTGGAATCATAAAGGCCATCCAGCTGTGTATGTGTCCACCTCCATTTCACTGGCCTCACTGGAGATTTTGGTGCACGTTC
GAAAAGATACTGTACTGAATCAGTACCAGCTTTTCAGCATTGATATCCCGGATGACCAGATTGATTACCTGGATAAAGCG
TGGCTCCCCGAGGACTGGCAGGAAAATCCGGCCCCCGTATCAACGATGGATCTGGGAACCGGTTGGTTGCAGGCTAACAG
CGCCCTCGCACTCATCTTACCCTCCTGCATCATTCCTTATGAAAACAATGCCATCCTTAACCCCTTACATCCGTCCTTCC
ACACGGCGCTCAATTCAGTTCAGCAACTGCCCTTTAATTTTGATACCCGCCTGGCTGAAAAAACCGCACCCTGA
Antitoxin
Download Length: 148 a.a. Molecular weight: 16349.68 Da Isoelectric Point: 7.2062
>AT34659 WP_023337017.1 NZ_AP022126:c1762864-1762421 [Enterobacter cloacae]
MRTWIPAQKPADNALWRYAGLPANRGMRLIEFLNQGLPVSVLDNIHEWTAMSKADILRVTGINERNVARRKSAGRTLTPD
ESERVARFVRVLDAAVDYFGSKEEAWNWLQAPVRGLGNVAPVDLIATETGALEVTDLIGRLEHGVFA
MRTWIPAQKPADNALWRYAGLPANRGMRLIEFLNQGLPVSVLDNIHEWTAMSKADILRVTGINERNVARRKSAGRTLTPD
ESERVARFVRVLDAAVDYFGSKEEAWNWLQAPVRGLGNVAPVDLIATETGALEVTDLIGRLEHGVFA
Download Length: 444 bp
>AT34659 NZ_AP022126:c1762864-1762421 [Enterobacter cloacae]
ATGAGAACATGGATCCCCGCGCAGAAACCTGCTGATAACGCGCTTTGGCGGTACGCCGGTTTACCTGCAAACAGAGGTAT
GCGGCTGATTGAATTTCTCAATCAGGGATTACCCGTCAGCGTCCTCGACAATATCCATGAGTGGACGGCGATGTCGAAAG
CGGACATTTTGCGCGTCACCGGAATTAATGAACGTAACGTGGCCCGGCGCAAAAGCGCGGGACGGACGCTGACGCCGGAT
GAAAGCGAACGCGTGGCCCGTTTCGTTCGGGTGCTGGATGCTGCTGTCGACTATTTTGGCAGTAAAGAAGAGGCATGGAA
CTGGCTGCAGGCACCGGTGCGCGGGCTAGGGAATGTTGCCCCTGTCGACCTGATCGCGACCGAAACCGGTGCACTGGAAG
TCACCGACTTGATTGGTCGACTCGAACATGGTGTGTTCGCATGA
ATGAGAACATGGATCCCCGCGCAGAAACCTGCTGATAACGCGCTTTGGCGGTACGCCGGTTTACCTGCAAACAGAGGTAT
GCGGCTGATTGAATTTCTCAATCAGGGATTACCCGTCAGCGTCCTCGACAATATCCATGAGTGGACGGCGATGTCGAAAG
CGGACATTTTGCGCGTCACCGGAATTAATGAACGTAACGTGGCCCGGCGCAAAAGCGCGGGACGGACGCTGACGCCGGAT
GAAAGCGAACGCGTGGCCCGTTTCGTTCGGGTGCTGGATGCTGCTGTCGACTATTTTGGCAGTAAAGAAGAGGCATGGAA
CTGGCTGCAGGCACCGGTGCGCGGGCTAGGGAATGTTGCCCCTGTCGACCTGATCGCGACCGAAACCGGTGCACTGGAAG
TCACCGACTTGATTGGTCGACTCGAACATGGTGTGTTCGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J0PLX5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J0PMR8 |