Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 550063..550579 Replicon chromosome
Accession NZ_AP022126
Organism Enterobacter cloacae strain WP5-S18-CRE-02

Toxin (Protein)


Gene name relE Uniprot ID A0A2J0PPK2
Locus tag H7R61_RS02710 Protein ID WP_014882291.1
Coordinates 550295..550579 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag H7R61_RS02705 Protein ID WP_008501400.1
Coordinates 550063..550305 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R61_RS02690 546158..546901 + 744 WP_023331886.1 KDGP aldolase family protein -
H7R61_RS02695 546919..548055 + 1137 WP_014882289.1 lactonase family protein -
H7R61_RS02700 548075..549985 + 1911 WP_014882290.1 BglG family transcription antiterminator -
H7R61_RS02705 550063..550305 + 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H7R61_RS02710 550295..550579 + 285 WP_014882291.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7R61_RS02715 550583..551047 - 465 WP_014882292.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
H7R61_RS02720 551189..553327 - 2139 WP_014882293.1 anaerobic ribonucleoside-triphosphate reductase -
H7R61_RS02725 553697..554269 - 573 WP_014882294.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10894.69 Da        Isoelectric Point: 10.1988

>T34656 WP_014882291.1 NZ_AP022126:550295-550579 [Enterobacter cloacae]
MTYELVFDPRALKEWSKLGDTVKNQFKKKLADVLVNPRVESARLHGLPDCYKIKLRSQGYRLVYQVQDDVVTVFVIAVGK
REKSAVYHDANKRL

Download         Length: 285 bp

>T34656 NZ_AP022126:550295-550579 [Enterobacter cloacae]
ATGACTTATGAACTGGTATTTGACCCGAGGGCGTTAAAGGAGTGGAGCAAGCTGGGCGATACCGTAAAAAACCAATTTAA
GAAGAAGCTTGCGGACGTGTTGGTGAATCCCAGGGTTGAATCGGCTCGCCTGCATGGCCTGCCTGATTGCTACAAGATAA
AACTGAGATCCCAGGGTTATCGTTTGGTCTATCAGGTTCAGGATGACGTTGTAACGGTATTTGTTATTGCTGTCGGTAAG
AGAGAGAAGTCAGCCGTTTATCATGACGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT34656 WP_008501400.1 NZ_AP022126:550063-550305 [Enterobacter cloacae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp

>AT34656 NZ_AP022126:550063-550305 [Enterobacter cloacae]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTCAATATCACGCC
AACGGAAGCTGTGCGTTTACTGTTTCAGTATGTCGCGGAAACGGGACGCATGCCGGTGAAAACGGTCACCATTAGCGACA
GTGAAGATGCACTGATACAGACAGTCCGGGAGCGACTGGCTAATCCGCAAAAGGGAATCAAGGTCAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PPK2

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References