Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 57375..57900 Replicon plasmid pWP5-W18-ESBL-06_1
Accession NZ_AP022113
Organism Klebsiella quasipneumoniae strain WP5-W18-ESBL-06

Toxin (Protein)


Gene name ccdB Uniprot ID A0A9E1GGX2
Locus tag H7R83_RS26990 Protein ID WP_016946795.1
Coordinates 57595..57900 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A9E1GDP8
Locus tag H7R83_RS26985 Protein ID WP_004197642.1
Coordinates 57375..57593 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R83_RS26955 52915..53919 + 1005 WP_136392550.1 LacI family DNA-binding transcriptional regulator -
H7R83_RS26960 54303..55000 - 698 Protein_57 IS1 family transposase -
H7R83_RS26965 55057..56070 - 1014 Protein_58 AAA family ATPase -
H7R83_RS26970 56144..56560 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin -
H7R83_RS26975 56557..56787 - 231 WP_001261282.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
H7R83_RS26980 56744..57205 + 462 WP_162574861.1 hypothetical protein -
H7R83_RS26985 57375..57593 + 219 WP_004197642.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
H7R83_RS26990 57595..57900 + 306 WP_016946795.1 type II toxin-antitoxin system toxin CcdB Toxin
H7R83_RS26995 58129..58269 + 141 WP_162898808.1 hypothetical protein -
H7R83_RS27000 58319..58654 + 336 WP_009309920.1 hypothetical protein -
H7R83_RS27005 58688..59704 + 1017 WP_009309921.1 hypothetical protein -
H7R83_RS27010 59902..60681 + 780 WP_023287113.1 site-specific integrase -
H7R83_RS27015 60739..60996 - 258 WP_009310077.1 hypothetical protein -
H7R83_RS27020 61125..61238 - 114 WP_014343462.1 hypothetical protein -
H7R83_RS27025 61801..62826 + 1026 WP_001101446.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..190538 190538
- flank IS/Tn - - 54303..54806 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11548.22 Da        Isoelectric Point: 5.6831

>T34612 WP_016946795.1 NZ_AP022113:57595-57900 [Klebsiella quasipneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSCELYPVVHIGDDSYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T34612 NZ_AP022113:57595-57900 [Klebsiella quasipneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCTGTGAACTCTATCCGGTGG
TGCACATCGGGGACGACAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8376.34 Da        Isoelectric Point: 4.7405

>AT34612 WP_004197642.1 NZ_AP022113:57375-57593 [Klebsiella quasipneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT34612 NZ_AP022113:57375-57593 [Klebsiella quasipneumoniae]
ATGAAGCAGCGCATCACCGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCTGAAAATCAGGAAGGAATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References