Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 808017..808674 Replicon chromosome
Accession NZ_AP022112
Organism Klebsiella quasipneumoniae strain WP5-W18-ESBL-06

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag H7R83_RS03985 Protein ID WP_004205323.1
Coordinates 808264..808674 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag H7R83_RS03980 Protein ID WP_002916312.1
Coordinates 808017..808283 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R83_RS03955 803225..804658 - 1434 WP_004205314.1 6-phospho-beta-glucosidase BglA -
H7R83_RS03960 804777..805505 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
H7R83_RS03965 805556..805867 + 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
H7R83_RS03970 806030..806689 + 660 WP_004205319.1 hemolysin III family protein -
H7R83_RS03975 806788..807771 - 984 WP_017899798.1 tRNA-modifying protein YgfZ -
H7R83_RS03980 808017..808283 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
H7R83_RS03985 808264..808674 + 411 WP_004205323.1 protein YgfX Toxin
H7R83_RS03990 808681..809202 - 522 WP_109938288.1 flavodoxin FldB -
H7R83_RS03995 809303..810199 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
H7R83_RS04000 810222..810935 + 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H7R83_RS04005 810941..812674 + 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T34597 WP_004205323.1 NZ_AP022112:808264-808674 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T34597 NZ_AP022112:808264-808674 [Klebsiella quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCACTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGCGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GACTGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT34597 WP_002916312.1 NZ_AP022112:808017-808283 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT34597 NZ_AP022112:808017-808283 [Klebsiella quasipneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References