Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 140837..141393 Replicon plasmid pWP5-W18-ESBL-02_1
Accession NZ_AP022111
Organism Aeromonas caviae strain WP5-W18-ESBL-02

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag H7R67_RS23220 Protein ID WP_182936448.1
Coordinates 140837..141112 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag H7R67_RS23225 Protein ID WP_182936447.1
Coordinates 141112..141393 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R67_RS23195 135906..136211 + 306 WP_005320934.1 hypothetical protein -
H7R67_RS23200 136313..137716 - 1404 WP_182959202.1 IS66-like element ISAs21 family transposase -
H7R67_RS23205 137803..139056 + 1254 WP_042650430.1 IS256-like element ISAeme25 family transposase -
H7R67_RS23210 139440..139763 - 324 Protein_134 IS30 family transposase -
H7R67_RS23215 140059..140787 - 729 WP_182936449.1 carbonic anhydrase -
H7R67_RS23220 140837..141112 - 276 WP_182936448.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7R67_RS23225 141112..141393 - 282 WP_182936447.1 ribbon-helix-helix domain-containing protein Antitoxin
H7R67_RS23230 141651..142211 + 561 WP_001161490.1 recombinase family protein -
H7R67_RS23235 142215..145181 + 2967 WP_001138014.1 Tn3-like element TnAs1 family transposase -
H7R67_RS23240 145178..145783 - 606 WP_182959078.1 replication initiation protein -
H7R67_RS23245 146191..146388 - 198 WP_182959080.1 chromosome partitioning protein ParB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..147986 147986
- inside IScluster/Tn - - 136313..145181 8868


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-50)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10676.43 Da        Isoelectric Point: 9.5291

>T34594 WP_182936448.1 NZ_AP022111:c141112-140837 [Aeromonas caviae]
MELKWTSKALSDLTRLYEFLALANKPAAARVVQALTQAPAILLTNPRIGEQLFQFEPREVRRMLVGEYEVRYELLDSSIY
ILRLWHTREAR

Download         Length: 276 bp

>T34594 NZ_AP022111:c141112-140837 [Aeromonas caviae]
ATGGAACTGAAGTGGACCAGCAAAGCGCTCTCTGATTTGACACGCTTGTATGAATTTTTGGCTCTGGCTAACAAACCCGC
CGCGGCTCGGGTAGTGCAGGCACTGACACAGGCCCCAGCTATTCTGCTAACAAACCCGCGTATTGGAGAACAACTGTTCC
AATTCGAGCCCCGCGAGGTGAGGAGGATGTTGGTTGGAGAATACGAGGTTCGTTACGAGCTCCTTGATTCGAGCATCTAC
ATTCTGCGGCTGTGGCATACCCGAGAAGCTCGTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10368.83 Da        Isoelectric Point: 5.6706

>AT34594 WP_182936447.1 NZ_AP022111:c141393-141112 [Aeromonas caviae]
MKSNMTQATTKVLTAHVPLPMADKVDQMAARLERSRGWIMKQALSAWIAQEEDRDRLTQEALADVEAGRVIDHLAVQAWA
DSLSTDQPLSVPR

Download         Length: 282 bp

>AT34594 NZ_AP022111:c141393-141112 [Aeromonas caviae]
ATGAAGAGCAACATGACACAAGCAACAACCAAGGTGCTTACTGCACACGTACCACTACCTATGGCCGACAAAGTTGACCA
GATGGCAGCCCGCCTTGAACGCTCACGGGGCTGGATCATGAAACAGGCTCTTTCCGCATGGATCGCCCAGGAAGAGGATC
GTGATCGCCTGACCCAAGAGGCGCTGGCAGACGTGGAAGCTGGTCGAGTTATCGATCACTTGGCGGTGCAGGCTTGGGCT
GACAGCCTCAGTACTGACCAGCCGCTGTCGGTTCCGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References