Detailed information of TA system TA034592

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 4721759..4722327
• Replicon: chromosome
• Accession: NZ_AP022110
• Organism: Aeromonas caviae strain WP5-W18-ESBL-02

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A0D0R3P1
• Locus tag: H7R67_RS22375
• Protein ID: WP_011222050.1
• Coordinates: 4722034..4722327 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A6M3UV67
• Locus tag: H7R67_RS22370
• Protein ID: WP_011222051.1
• Coordinates: 4721759..4722046 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R67_RS22345	4717086..4717874	+	789	WP_182959016.1	dihydropteroate synthase	-
H7R67_RS22350	4718002..4718502	+	501	WP_000376623.1	GNAT family N-acetyltransferase	-
H7R67_RS22355	4718471..4719463	-	993	WP_134996545.1	TniB family NTP-binding protein	-
H7R67_RS22360	4719466..4721145	-	1680	WP_000179844.1	DDE-type integrase/transposase/recombinase	-
H7R67_RS22365	4721410..4721586	+	177	WP_167576894.1	hypothetical protein	-
H7R67_RS22370	4721759..4722046	+	288	WP_011222051.1	CopG family ribbon-helix-helix protein	Antitoxin
H7R67_RS22375	4722034..4722327	+	294	WP_011222050.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H7R67_RS22380	4722265..4722576	-	312	WP_052150402.1	hypothetical protein	-
H7R67_RS22385	4722612..4722797	-	186	Protein_4318	multidrug transporter	-
H7R67_RS22390	4723226..4723468	+	243	WP_000844627.1	transposase	-
H7R67_RS22395	4723500..4724150	-	651	WP_000164043.1	tetracycline resistance transcriptional repressor TetR(A)	-
H7R67_RS22400	4724256..4725455	+	1200	WP_001973670.1	tetracycline efflux MFS transporter Tet(A)	-
H7R67_RS22405	4725487..4725759	-	273	Protein_4322	EamA family transporter	-
H7R67_RS22415	4726119..4726748	+	630	WP_134695567.1	recombinase family protein	-
H7R67_RS22420	4726733..4727056	-	324	WP_134695568.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	ant(2'')-Ia / blaOXA-10 / aadA2 / aph(3'')-Ib / aph(6)-Id / sul1 / tet(A)	-	4700137..4743998	43861

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-45)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10890.71 Da
• Isoelectric Point: 10.8518

>T34592 WP_011222050.1 NZ_AP022110:4722034-4722327 [Aeromonas caviae]
MPQVILSPAALRDLKRLREFLHSKSPVVAQRAAQTIRSALAQLGQQPAMGRPIEGLPEVFREWVIPFGDSGYLARYRLEG
ETVVILALRHQREAGFI

Nucleotide

• Length: 294 bp

>T34592 NZ_AP022110:4722034-4722327 [Aeromonas caviae]
ATGCCACAAGTGATCCTCTCTCCGGCTGCTCTGCGTGACCTTAAACGGCTGCGCGAGTTCTTGCACAGTAAGAGCCCAGT
TGTTGCACAGCGAGCAGCCCAAACCATCCGTTCGGCGCTGGCCCAGCTCGGGCAACAACCCGCGATGGGGCGTCCTATTG
AAGGGCTCCCGGAGGTGTTCCGCGAGTGGGTCATCCCCTTTGGGGACAGTGGTTATCTGGCGCGTTACCGCCTAGAGGGC
GAAACCGTAGTGATCTTGGCTCTGCGTCACCAGCGCGAAGCCGGGTTTATTTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10922.19 Da
• Isoelectric Point: 5.1897

>AT34592 WP_011222051.1 NZ_AP022110:4721759-4722046 [Aeromonas caviae]
MSAATKPMSIKLDSDTQSRIKQLAAARDRSAHWMMREAITQYVEREERKEAFRRDTLDAWQEFQETGLHVSLEETDQWLA
GWGTEIEGGAPACHK

Nucleotide

• Length: 288 bp

>AT34592 NZ_AP022110:4721759-4722046 [Aeromonas caviae]
ATGTCCGCAGCTACCAAACCCATGTCTATCAAACTTGATAGCGATACCCAAAGCCGGATCAAGCAGCTAGCTGCTGCCCG
CGACCGTTCAGCGCACTGGATGATGCGCGAAGCTATCACCCAGTATGTTGAGCGCGAAGAGCGCAAGGAGGCGTTCCGCC
GCGATACCCTCGATGCTTGGCAGGAGTTTCAGGAGACTGGTTTGCATGTCTCTCTTGAGGAGACCGATCAGTGGTTGGCT
GGTTGGGGCACCGAGATTGAAGGTGGTGCACCTGCATGCCACAAGTGA

Structures

Toxin

• AlphaFold DB: A0A0D0R3P1

Antitoxin

• AlphaFold DB: A0A6M3UV67