34590

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 3439154..3440868 Replicon chromosome
Accession NZ_AP022110
Organism Aeromonas caviae strain WP5-W18-ESBL-02

Toxin (Protein)


Gene name pmenT Uniprot ID A0A6S5IKK5
Locus tag H7R67_RS15955 Protein ID WP_049636669.1
Coordinates 3440215..3440868 (-) Length 218 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID A0A6I4WU85
Locus tag H7R67_RS15950 Protein ID WP_041206015.1
Coordinates 3439154..3440218 (-) Length 355 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R67_RS15935 3434278..3435216 + 939 WP_021138001.1 restriction endonuclease -
H7R67_RS15940 3435235..3435948 - 714 WP_182954681.1 M48 family metallopeptidase -
H7R67_RS15945 3435948..3439079 - 3132 WP_182954683.1 HsdR family type I site-specific deoxyribonuclease -
H7R67_RS15950 3439154..3440218 - 1065 WP_041206015.1 macro domain-containing protein Antitoxin
H7R67_RS15955 3440215..3440868 - 654 WP_049636669.1 DUF4433 domain-containing protein Toxin
H7R67_RS15960 3440875..3442911 - 2037 WP_049636668.1 DUF262 domain-containing HNH endonuclease family protein -
H7R67_RS15965 3442920..3444368 - 1449 WP_049636682.1 DUF262 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3430188..3477681 47493
- flank IS/Tn - - 3444860..3446134 1274


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(17-216)

Antitoxin

Macro domain

(18-131)


Sequences

Toxin        


Download         Length: 218 a.a.        Molecular weight: 25229.78 Da        Isoelectric Point: 6.8260

>T34590 WP_049636669.1 NZ_AP022110:c3440868-3440215 [Aeromonas caviae]
MGYDYSQSLNPQKALIFRIVHRDNLEWILTHGLWAGNGQQQSPHWVHIGLPELIAKRARHPVPLAPYGVLNDYVPFYFTP
FSPMLSNIHSGRGVPQRENDEILILVSSLHRIAELGLPFVFTDSHAYYQWANFYVDLGDLGRIDWPLLQRRDFKRDAEDL
SKLERYQAEALIHQHCPIEALLGVVCYNEEIKNSVEQCMNRVGVARPVYVRDGWYFR

Download         Length: 654 bp

>T34590 NZ_AP022110:c3440868-3440215 [Aeromonas caviae]
ATGGGTTATGACTATAGCCAGAGCCTGAATCCGCAGAAGGCGCTGATATTCCGGATCGTGCATCGGGATAATCTGGAATG
GATCCTGACCCATGGCCTGTGGGCGGGGAATGGTCAGCAGCAAAGCCCGCACTGGGTGCATATCGGGTTGCCGGAGCTGA
TTGCCAAGCGCGCGCGCCATCCGGTGCCGCTGGCGCCTTACGGCGTGTTGAATGACTATGTGCCCTTCTACTTCACGCCG
TTTTCTCCCATGCTCAGCAATATTCACTCAGGGCGCGGTGTTCCCCAGCGTGAAAATGATGAAATCTTGATCCTGGTTTC
CAGCCTGCATCGCATAGCTGAATTGGGGCTACCGTTTGTGTTTACCGATAGCCATGCCTATTACCAGTGGGCCAATTTCT
ATGTCGATCTTGGCGATCTGGGGCGGATTGACTGGCCACTGTTGCAGCGCCGTGACTTCAAGCGTGATGCGGAAGATTTG
AGCAAGCTGGAACGCTATCAGGCCGAGGCCTTGATCCATCAACATTGCCCCATCGAGGCGTTGCTGGGCGTGGTGTGTTA
CAACGAAGAAATAAAGAACAGCGTGGAACAATGCATGAATCGGGTCGGGGTCGCGCGCCCCGTCTATGTCCGTGATGGGT
GGTATTTCAGATGA

Antitoxin


Download         Length: 355 a.a.        Molecular weight: 39588.70 Da        Isoelectric Point: 6.5002

>AT34590 WP_041206015.1 NZ_AP022110:c3440218-3439154 [Aeromonas caviae]
MIRYTTGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPANMRAYAEACKQGDVVTGKMFITQTGELLGPRWIVNFPTK
QHWRNPAQMAWIQDGLQDLRAWLQAQQVSSIAIPPLGAGNGGLPWPEVKQAIETALGDLDIDILLYEPSSQYQNVAKRGG
VAELTPARALIAELVRRYWFLGMECSLLEIQKLAWFLARVIGRNPLGDPLQLQFKAHRYGPYANNLTHLLNAMDGSYLQS
DKRIPDSKPFDVIWFNEAKKQELAVYLQTEAKAFLPILEQTTALIDGFESPYGMELLATVDWLIAEEGCAPTLSALREGL
HRWPAGTPWGERKARLFDDRSLQIALTRLQQGLV

Download         Length: 1065 bp

>AT34590 NZ_AP022110:c3440218-3439154 [Aeromonas caviae]
ATGATTCGATATACAACAGGCAATCTGCTGGATGCTCCGGTTGAAGCACTGGTGAATACCGTCAACACCGTCGGTGTCAT
GGGCAAGGGGATCGCCTTGATGTTCAAAGAGCGGTTCCCGGCCAATATGCGTGCCTATGCCGAGGCGTGCAAGCAGGGTG
ATGTCGTCACCGGCAAGATGTTTATTACCCAGACGGGTGAGCTGCTAGGGCCGCGCTGGATCGTGAATTTTCCGACCAAA
CAGCACTGGCGCAATCCGGCACAGATGGCGTGGATCCAGGACGGTTTGCAGGATCTGCGGGCCTGGTTACAGGCGCAGCA
GGTCTCCTCGATTGCCATTCCACCACTGGGGGCTGGCAACGGCGGTCTGCCTTGGCCGGAGGTCAAACAGGCGATCGAAA
CGGCACTGGGCGATCTGGATATCGATATCCTGCTCTATGAGCCCAGTAGCCAATACCAAAATGTGGCCAAGCGCGGCGGG
GTGGCGGAGCTGACTCCGGCCCGGGCCCTGATTGCTGAACTGGTGCGTCGCTACTGGTTTTTAGGGATGGAGTGCAGCTT
GCTGGAGATCCAGAAACTGGCCTGGTTTCTGGCTCGGGTCATTGGCCGTAACCCGCTGGGGGATCCGCTGCAGTTGCAGT
TTAAGGCCCATCGTTATGGCCCTTATGCCAACAATCTGACCCATCTGCTCAATGCGATGGACGGCAGTTATCTGCAGTCC
GACAAGCGCATCCCGGATAGCAAGCCGTTTGATGTCATCTGGTTTAATGAGGCTAAAAAACAAGAGCTTGCCGTTTATCT
CCAGACCGAGGCCAAAGCATTTTTACCGATACTGGAGCAGACGACCGCGTTAATCGATGGTTTTGAGTCGCCCTATGGCA
TGGAGTTATTGGCCACGGTGGATTGGTTGATCGCCGAAGAGGGCTGTGCGCCGACACTGAGCGCGCTGCGCGAGGGGTTG
CATCGCTGGCCAGCGGGAACCCCGTGGGGTGAGCGCAAGGCGCGGCTGTTTGATGATCGCAGCCTGCAGATCGCCTTGAC
CCGTTTGCAGCAGGGATTGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6S5IKK5

Antitoxin

Source ID Structure
AlphaFold DB A0A6I4WU85

References