Detailed information of TA system TA034588

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 204239..205140
• Replicon: plasmid pWP5-W18-CRE-01_1
• Accession: NZ_AP022109
• Organism: Klebsiella aerogenes strain WP5-W18-CRE-01

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A837LJP8
• Locus tag: H7R63_RS25275
• Protein ID: WP_007372300.1
• Coordinates: 204239..204697 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: H7R63_RS25280
• Protein ID: WP_008786588.1
• Coordinates: 204694..205140 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R63_RS25230	199965..200207	+	243	WP_007372291.1	hypothetical protein	-
H7R63_RS25235	200218..200616	+	399	WP_007372292.1	hypothetical protein	-
H7R63_RS25240	200700..201026	+	327	WP_007372293.1	hypothetical protein	-
H7R63_RS25245	201389..201727	-	339	WP_007372294.1	hypothetical protein	-
H7R63_RS25250	201965..202408	+	444	WP_007372295.1	hypothetical protein	-
H7R63_RS25255	202527..202868	+	342	WP_007372296.1	hypothetical protein	-
H7R63_RS25260	203027..203581	+	555	WP_007372297.1	hypothetical protein	-
H7R63_RS25265	203631..203897	+	267	WP_007372298.1	hypothetical protein	-
H7R63_RS25270	203965..204195	-	231	WP_007372299.1	hypothetical protein	-
H7R63_RS25275	204239..204697	-	459	WP_007372300.1	RES family NAD+ phosphorylase	Toxin
H7R63_RS25280	204694..205140	-	447	WP_008786588.1	DUF2384 domain-containing protein	Antitoxin
H7R63_RS25285	205289..205606	+	318	WP_007372302.1	hypothetical protein	-
H7R63_RS25290	205648..206490	+	843	WP_007372303.1	hypothetical protein	-
H7R63_RS25295	206462..206740	+	279	WP_007372304.1	hypothetical protein	-
H7R63_RS25300	206800..207243	+	444	WP_007372305.1	hypothetical protein	-
H7R63_RS25305	207530..207694	+	165	WP_007372306.1	hypothetical protein	-
H7R63_RS25310	208262..209104	+	843	WP_007372307.1	HNH endonuclease	-
H7R63_RS25315	209526..209777	+	252	WP_024196080.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	formA	-	1..326767	326767

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (95-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16975.40 Da
• Isoelectric Point: 4.5730

>T34588 WP_007372300.1 NZ_AP022109:c204697-204239 [Klebsiella aerogenes]
VILYRLTKTRYLMTAWSGLGAKEAGGRWNSVGTAMVYLSETASLTMLETLVHIHAPQLLDDFTLLSLDVPDDQIQTFDMS
RLPDNWASEDAPAELALYGDNWAESGSSIALRIPSALSPVEFNYLLNPAHPELFDLMATVKKIPFRFDSRLK

Nucleotide

• Length: 459 bp

>T34588 NZ_AP022109:c204697-204239 [Klebsiella aerogenes]
GTGATCCTTTACCGACTGACCAAGACCCGTTATCTGATGACTGCGTGGTCTGGTCTGGGTGCGAAAGAAGCGGGGGGCCG
CTGGAACAGCGTAGGCACTGCAATGGTCTACCTGTCTGAAACGGCCAGCCTTACCATGCTTGAAACGCTGGTACACATTC
ACGCGCCGCAGTTACTGGACGACTTTACACTGCTGAGTCTTGATGTACCGGATGATCAGATCCAGACCTTCGACATGAGC
CGTCTCCCTGATAACTGGGCGAGTGAGGATGCTCCTGCTGAGCTGGCGCTCTACGGTGATAACTGGGCTGAAAGCGGTTC
TTCTATCGCGCTGCGTATTCCAAGTGCGTTGTCTCCGGTTGAATTTAACTACTTGCTGAATCCGGCACACCCTGAACTCT
TTGACCTGATGGCTACGGTTAAGAAAATTCCGTTCCGGTTTGATTCCCGCCTGAAATAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16689.02 Da
• Isoelectric Point: 6.9812

>AT34588 WP_008786588.1 NZ_AP022109:c205140-204694 [Klebsiella aerogenes]
MTMKVFSPDVTKTNQHCLWQVAGLDNDGIALMDKINHGLDGTVAKHISEWANITPSELRKMSGIPNTTFNRSIKDRFTAD
QSERLVRIIRVIERAVELFEGDKEAAHKWLNEANRGLSWKSPAELVSSETGALEVMRLITRIEHGVYS

Nucleotide

• Length: 447 bp

>AT34588 NZ_AP022109:c205140-204694 [Klebsiella aerogenes]
ATGACGATGAAAGTTTTTTCTCCAGACGTTACCAAAACGAATCAGCACTGCTTATGGCAGGTTGCTGGGCTGGATAATGA
CGGTATCGCGCTGATGGATAAAATCAATCACGGTCTCGATGGCACAGTAGCTAAGCACATTTCTGAATGGGCTAACATCA
CGCCGTCTGAGCTGCGCAAAATGTCGGGTATACCTAATACGACGTTTAATCGTAGCATCAAAGACCGTTTCACTGCCGAT
CAGAGCGAACGTCTGGTGCGCATTATCCGCGTAATTGAACGCGCTGTAGAGCTGTTTGAAGGTGACAAAGAAGCGGCGCA
CAAATGGCTGAACGAAGCGAACCGTGGTCTGAGCTGGAAATCACCGGCAGAGCTTGTTTCTTCTGAGACAGGTGCGCTTG
AAGTGATGCGCCTGATTACGCGTATTGAGCACGGGGTATACTCGTGA

Structures

Toxin

• AlphaFold DB: A0A837LJP8