Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2424647..2425285 Replicon chromosome
Accession NZ_AP022105
Organism Escherichia coli strain WP5-S17-ESBL-10

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag H7R00_RS11485 Protein ID WP_000813794.1
Coordinates 2425109..2425285 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H7R00_RS11480 Protein ID WP_001270286.1
Coordinates 2424647..2425063 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R00_RS11460 2419799..2420740 - 942 WP_001251304.1 ABC transporter permease -
H7R00_RS11465 2420741..2421754 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
H7R00_RS11470 2421772..2422917 - 1146 WP_069905164.1 ABC transporter substrate-binding protein -
H7R00_RS11475 2423162..2424568 - 1407 WP_069905165.1 PLP-dependent aminotransferase family protein -
H7R00_RS11480 2424647..2425063 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
H7R00_RS11485 2425109..2425285 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
H7R00_RS11490 2425507..2425737 + 231 WP_000494244.1 YncJ family protein -
H7R00_RS11495 2425829..2427790 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
H7R00_RS11500 2427863..2428399 - 537 WP_115776208.1 DNA-binding transcriptional regulator SutR -
H7R00_RS11505 2428452..2429666 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T34532 WP_000813794.1 NZ_AP022105:c2425285-2425109 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T34532 NZ_AP022105:c2425285-2425109 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT34532 WP_001270286.1 NZ_AP022105:c2425063-2424647 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT34532 NZ_AP022105:c2425063-2424647 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References