Detailed information of TA system TA034515

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 4707513..4708501
• Replicon: chromosome
• Accession: NZ_AP022098
• Organism: Escherichia coli strain WP4-S18-ESBL-09

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: H7R19_RS22605
• Protein ID: WP_014640052.1
• Coordinates: 4707513..4707899 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A0J5Z6D5
• Locus tag: H7R19_RS22610
• Protein ID: WP_000458584.1
• Coordinates: 4707929..4708501 (-)
• Length: 191 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R19_RS22555	4702601..4702846	-	246	WP_000141753.1	hypothetical protein	-
H7R19_RS22560	4702959..4703269	+	311	Protein_4425	hypothetical protein	-
H7R19_RS22565	4703284..4703646	+	363	WP_000135682.1	hypothetical protein	-
H7R19_RS22570	4703712..4704536	+	825	WP_089438609.1	DUF2303 family protein	-
H7R19_RS22575	4704664..4705200	+	537	WP_000008200.1	5'-deoxynucleotidase	-
H7R19_RS22580	4705191..4705553	+	363	WP_001565177.1	phage protein	-
H7R19_RS22585	4705553..4706362	+	810	WP_000206745.1	hypothetical protein	-
H7R19_RS22590	4706362..4706934	+	573	WP_001061348.1	3'-5' exoribonuclease	-
H7R19_RS22595	4706971..4707252	+	282	WP_001093917.1	pyocin activator PrtN family protein	-
H7R19_RS22600	4707300..4707473	-	174	WP_000390072.1	hypothetical protein	-
H7R19_RS22605	4707513..4707899	-	387	WP_014640052.1	hypothetical protein	Toxin
H7R19_RS22610	4707929..4708501	-	573	WP_000458584.1	SocA family protein	Antitoxin
H7R19_RS22615	4708737..4708859	-	123	WP_001300034.1	hypothetical protein	-
H7R19_RS22620	4709221..4710225	-	1005	WP_022646425.1	DUF2713 family protein	-
H7R19_RS22625	4710543..4711058	+	516	WP_000416263.1	zinc uptake transcriptional repressor Zur	-
H7R19_RS22630	4711100..4711309	-	210	WP_001296638.1	CsbD family protein	-
H7R19_RS22635	4711425..4712750	-	1326	WP_001361471.1	MATE family efflux transporter DinF	-
H7R19_RS22640	4712823..4713431	-	609	WP_000646078.1	transcriptional repressor LexA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4667152..4713431	46279

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-137)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T34515 WP_014640052.1 NZ_AP022098:c4707899-4707513 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T34515 NZ_AP022098:c4707899-4707513 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATCTCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin

Protein

• Length: 191 a.a.
• Molecular weight: 21973.21 Da
• Isoelectric Point: 6.0283

>AT34515 WP_000458584.1 NZ_AP022098:c4708501-4707929 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHNVSLRSDPREMDADEVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Nucleotide

• Length: 573 bp

>AT34515 NZ_AP022098:c4708501-4707929 [Escherichia coli]
ATGTTTTGCGAAGAAAAAGTAGCTCAAATGGCTGCATACCTACTTCTTAAGCGAGGTGGGCGCATGGCATATCTGAAATT
GATGAAGTTGCTCTATCTGTCTAACCGCCAGTCGATTTTGAAGCATGGCAGGATGATCGGCGAAGATAGCCTTTACTCTA
TGAAATTTGGACCAGTCATGTCGAATACGCTGAACTTGATTCGCGGTAAGGCTGAAGGCATTGGTGACTACTGGTACAAC
TTGATAGAGACGAACGGGCATAATGTATCGTTGCGTTCAGATCCGAGGGAAATGGATGCAGACGAGGTCTTTGATGAATT
GAGTCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCGGTATGGGCATATGAACCGATTTGATCTCGCAAATATGA
CGCATTTAGAAAGCGTTTGTCCAGAGTGGCACGATCCTGGCAATTCTCGTAAGCCTATAGACCTGAAAGAAATGCTGATC
AGTGAGGGTAAAAGCGAGGATGAGGCTAATCGCATAATTGGCAAAATGGAAGAATCTCAGAAACTTAAGGAATTTTCTTT
GCAATTATCATGA

Structures

Antitoxin

• AlphaFold DB: A0A0J5Z6D5