Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2642019..2642657 Replicon chromosome
Accession NZ_AP022098
Organism Escherichia coli strain WP4-S18-ESBL-09

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag H7R19_RS12425 Protein ID WP_000813794.1
Coordinates 2642481..2642657 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H7R19_RS12420 Protein ID WP_001270286.1
Coordinates 2642019..2642435 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R19_RS12400 2637171..2638112 - 942 WP_022645667.1 ABC transporter permease -
H7R19_RS12405 2638113..2639126 - 1014 WP_022645666.1 ABC transporter ATP-binding protein -
H7R19_RS12410 2639144..2640289 - 1146 WP_000047466.1 ABC transporter substrate-binding protein -
H7R19_RS12415 2640534..2641940 - 1407 WP_022645665.1 PLP-dependent aminotransferase family protein -
H7R19_RS12420 2642019..2642435 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
H7R19_RS12425 2642481..2642657 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
H7R19_RS12430 2642879..2643109 + 231 WP_000491567.1 DUF2554 family protein -
H7R19_RS12435 2643201..2645162 - 1962 WP_023909195.1 23S rRNA 5-hydroxycytidine C2501 synthase -
H7R19_RS12440 2645235..2645771 - 537 WP_000429148.1 DNA-binding transcriptional regulator SutR -
H7R19_RS12445 2645824..2647035 + 1212 WP_071788120.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T34505 WP_000813794.1 NZ_AP022098:c2642657-2642481 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T34505 NZ_AP022098:c2642657-2642481 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTGAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT34505 WP_001270286.1 NZ_AP022098:c2642435-2642019 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT34505 NZ_AP022098:c2642435-2642019 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAACAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References