Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4960..5519 Replicon plasmid pWP4-S18-ESBL-07_1
Accession NZ_AP022088
Organism Escherichia coli strain WP4-S18-ESBL-07

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag H7R53_RS23535 Protein ID WP_085326186.1
Coordinates 4960..5235 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag H7R53_RS23540 Protein ID WP_085008810.1
Coordinates 5235..5519 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R53_RS23510 101..1315 + 1215 WP_085326192.1 DeoR family transcriptional regulator -
H7R53_RS23515 1329..2087 + 759 WP_001066367.1 hypothetical protein -
H7R53_RS23520 2178..3112 + 935 Protein_2 DMT family transporter -
H7R53_RS23525 3115..4150 + 1036 Protein_3 phosphotriesterase -
H7R53_RS23530 4573..4854 - 282 WP_085326188.1 hypothetical protein -
H7R53_RS23535 4960..5235 - 276 WP_085326186.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7R53_RS23540 5235..5519 - 285 WP_085008810.1 ribbon-helix-helix protein, CopG family Antitoxin
H7R53_RS23545 5949..6050 + 102 Protein_7 IS66 family insertion sequence element accessory protein TnpB -
H7R53_RS23550 6543..7706 - 1164 WP_085326184.1 hypothetical protein -
H7R53_RS23555 7703..10462 - 2760 WP_085326182.1 chromosome condensation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..183772 183772


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10751.46 Da        Isoelectric Point: 9.9324

>T34446 WP_085326186.1 NZ_AP022088:c5235-4960 [Escherichia coli]
MELKWTSKALSDLVRLYDFLVLASKPAAARTVQSLTQAAVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T34446 NZ_AP022088:c5235-4960 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGTGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGGCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10448.90 Da        Isoelectric Point: 5.6558

>AT34446 WP_085008810.1 NZ_AP022088:c5519-5235 [Escherichia coli]
MQMKNNSAQATKVITAHVPLLMADKVDQMAAKLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT34446 NZ_AP022088:c5519-5235 [Escherichia coli]
ATGCAAATGAAAAACAATAGTGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACTTATGGCTGATAAAGTCGA
CCAGATGGCCGCTAAACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References