Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 297188..297819 Replicon chromosome
Accession NZ_AP022087
Organism Escherichia coli strain WP4-S18-ESBL-07

Toxin (Protein)


Gene name hicA Uniprot ID A0A210B5N4
Locus tag H7R53_RS01270 Protein ID WP_033560611.1
Coordinates 297188..297439 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A210B5M4
Locus tag H7R53_RS01275 Protein ID WP_024044889.1
Coordinates 297460..297819 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R53_RS01255 292192..293259 + 1068 WP_024043585.1 HlyD family efflux transporter periplasmic adaptor subunit -
H7R53_RS01260 293256..295991 + 2736 WP_024216288.1 ribosome-associated ATPase/putative transporter RbbA -
H7R53_RS01265 295991..297115 + 1125 WP_001318088.1 ABC transporter permease -
H7R53_RS01270 297188..297439 + 252 WP_033560611.1 type II toxin-antitoxin system HicA family toxin Toxin
H7R53_RS01275 297460..297819 + 360 WP_024044889.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H7R53_RS01280 297938..298339 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
H7R53_RS01285 298345..299151 - 807 WP_000173688.1 nickel import ATP-binding protein NikE -
H7R53_RS01290 299148..299912 - 765 WP_001136200.1 nickel import ATP-binding protein NikD -
H7R53_RS01295 299912..300745 - 834 WP_001008957.1 nickel ABC transporter permease subunit NikC -
H7R53_RS01300 300742..301686 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9377.84 Da        Isoelectric Point: 10.4909

>T34421 WP_033560611.1 NZ_AP022087:297188-297439 [Escherichia coli]
MRTQVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDW

Download         Length: 252 bp

>T34421 NZ_AP022087:297188-297439 [Escherichia coli]
ATGAGAACCCAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAATCTCCTGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13370.23 Da        Isoelectric Point: 5.1797

>AT34421 WP_024044889.1 NZ_AP022087:297460-297819 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYAHTEKIKT
FTLRYPESLSERLTNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT34421 NZ_AP022087:297460-297819 [Escherichia coli]
ATGATCAAACTGAAGACACCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGTATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCATACAGAAAAGATTAAGACC
TTTACATTACGCTATCCAGAATCGCTGAGTGAACGCCTTACTAATGCGGCTGCGCAGCAACAAGTCTCTGTAAATACTTA
TATTATTGAAACGCTAAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A210B5N4

Antitoxin

Source ID Structure
AlphaFold DB A0A210B5M4

References