Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3472428..3473081 Replicon chromosome
Accession NZ_AP022077
Organism Acinetobacter baumannii strain WP4-W18-ESBL-11

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J8TGE7
Locus tag H7K53_RS16770 Protein ID WP_024437032.1
Coordinates 3472428..3472817 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag H7K53_RS16775 Protein ID WP_001288210.1
Coordinates 3472824..3473081 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7K53_RS16755 3467546..3469741 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
H7K53_RS16760 3469929..3470495 - 567 WP_000651536.1 rhombosortase -
H7K53_RS16765 3470573..3471658 - 1086 WP_000049106.1 hypothetical protein -
H7K53_RS16770 3472428..3472817 - 390 WP_024437032.1 membrane protein Toxin
H7K53_RS16775 3472824..3473081 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
H7K53_RS16780 3473269..3474441 + 1173 WP_017725189.1 acyl-CoA dehydrogenase family protein -
H7K53_RS16785 3474490..3475980 - 1491 WP_000415132.1 NAD(P)/FAD-dependent oxidoreductase -
H7K53_RS16790 3476162..3476539 - 378 WP_001216380.1 50S ribosomal protein L17 -
H7K53_RS16795 3476558..3477565 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15584.82 Da        Isoelectric Point: 10.3889

>T34396 WP_024437032.1 NZ_AP022077:c3472817-3472428 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAALFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYQSQNTV
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T34396 NZ_AP022077:c3472817-3472428 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGCTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT34396 WP_001288210.1 NZ_AP022077:c3473081-3472824 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT34396 NZ_AP022077:c3473081-3472824 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TGE7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References