34384

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 49386..49933 Replicon plasmid pWP4-W18-ESBL-09_2
Accession NZ_AP022071
Organism Escherichia coli strain WP4-W18-ESBL-09

Toxin (Protein)


Gene name parE Uniprot ID A0A896ZGX1
Locus tag H7R28_RS26170 Protein ID WP_000969997.1
Coordinates 49652..49933 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E0WH52
Locus tag H7R28_RS26165 Protein ID WP_000079932.1
Coordinates 49386..49655 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R28_RS26135 44727..44969 - 243 WP_021515452.1 PilI type IV pilus biogenesis protein -
H7R28_RS26140 45050..45193 - 144 WP_000176500.1 hypothetical protein -
H7R28_RS26145 45460..46122 - 663 WP_005082527.1 hypothetical protein -
H7R28_RS26150 46262..46903 - 642 WP_021515453.1 hypothetical protein -
H7R28_RS26155 47606..48478 + 873 WP_000729438.1 incFII family plasmid replication initiator RepA -
H7R28_RS26160 49173..49331 + 159 WP_000829588.1 hypothetical protein -
H7R28_RS26165 49386..49655 + 270 WP_000079932.1 hypothetical protein Antitoxin
H7R28_RS26170 49652..49933 + 282 WP_000969997.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7R28_RS26175 50770..51357 + 588 WP_001418189.1 serine acetyltransferase -
H7R28_RS26180 51639..52232 - 594 WP_001401779.1 hypothetical protein -
H7R28_RS26185 52586..53932 + 1347 WP_001132021.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..84553 84553
- flank IS/Tn - - 54264..54968 704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10879.54 Da        Isoelectric Point: 8.4615

>T34384 WP_000969997.1 NZ_AP022071:49652-49933 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YVLRVLHTAQKWP

Download         Length: 282 bp

>T34384 NZ_AP022071:49652-49933 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGTCGCAACGGTC
GTGTGGAAGGAACCCGGGAACTGGTTATTCACCCCCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATGTCCTGCGCGTGTTGCATACCGCACAGAAGTGGCCATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10268.58 Da        Isoelectric Point: 7.2055

>AT34384 WP_000079932.1 NZ_AP022071:49386-49655 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVSDK

Download         Length: 270 bp

>AT34384 NZ_AP022071:49386-49655 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCTGCCGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTTCCGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A896ZGX1

Antitoxin

Source ID Structure
AlphaFold DB A0A5U8RN22

References