34369

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2906441..2906922 Replicon chromosome
Accession NZ_AP022069
Organism Escherichia coli strain WP4-W18-ESBL-09

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7YS45
Locus tag H7R28_RS13870 Protein ID WP_014966210.1
Coordinates 2906632..2906922 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A0D7Y007
Locus tag H7R28_RS13865 Protein ID WP_000100896.1
Coordinates 2906441..2906632 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R28_RS13830 2902175..2902585 - 411 WP_033871096.1 DUF977 family protein -
H7R28_RS13835 2902601..2903371 - 771 WP_171874674.1 DUF1627 domain-containing protein -
H7R28_RS13840 2903393..2904139 - 747 WP_000788950.1 ATP-binding protein -
H7R28_RS13845 2904146..2905108 - 963 WP_032283173.1 helix-turn-helix domain-containing protein -
H7R28_RS13850 2905131..2905556 - 426 WP_000693845.1 Rha family transcriptional regulator -
H7R28_RS13855 2905540..2905815 - 276 WP_001048458.1 helix-turn-helix domain-containing protein -
H7R28_RS13860 2905923..2906423 + 501 WP_000824162.1 helix-turn-helix transcriptional regulator -
H7R28_RS13865 2906441..2906632 + 192 WP_000100896.1 hypothetical protein Antitoxin
H7R28_RS13870 2906632..2906922 + 291 WP_014966210.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7R28_RS13875 2907192..2907344 + 153 WP_021538048.1 DUF1391 family protein -
H7R28_RS13880 2907356..2907676 + 321 WP_001435739.1 hypothetical protein -
H7R28_RS13885 2907654..2907929 - 276 WP_000102678.1 hypothetical protein -
H7R28_RS13890 2908492..2908680 + 189 WP_000450218.1 cell division inhibitor -
H7R28_RS13895 2908677..2908868 + 192 WP_001093903.1 DUF1482 family protein -
H7R28_RS13900 2908961..2911432 + 2472 WP_097509247.1 exonuclease -
H7R28_RS13905 2911497..2911745 + 249 WP_000113189.1 excisionase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2861409..2914637 53228


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11176.05 Da        Isoelectric Point: 9.9854

>T34369 WP_014966210.1 NZ_AP022069:2906632-2906922 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLTEHPYLYPPSERVPSLREIVTHPNYIILYRVTASNIE
IVNVVHSRRQYPNKTC

Download         Length: 291 bp

>T34369 NZ_AP022069:2906632-2906922 [Escherichia coli]
ATGCTGCCCATTTTATGGCTACCTTCTGCACGTGATGATTTACGTCAGATCGTAGCCTATATTGCTAAGGAAAACCCTCC
CGCTGCACGTAGACTAAAAATACGCATTGAAACATCAGTTTTGTCACTTACTGAACACCCTTATCTGTACCCACCGAGCG
AAAGAGTTCCAAGTCTTCGTGAGATAGTGACTCATCCTAACTACATAATACTTTACCGAGTAACAGCATCTAACATCGAG
ATCGTAAATGTAGTTCACTCACGAAGACAGTATCCAAACAAAACCTGTTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7033.83 Da        Isoelectric Point: 4.0270

>AT34369 WP_000100896.1 NZ_AP022069:2906441-2906632 [Escherichia coli]
MSTALSPIISEFETVEQENSYNEWLRTKVAASLSDPRPAIPHDEVMAEMENLIAQLAATNRSE

Download         Length: 192 bp

>AT34369 NZ_AP022069:2906441-2906632 [Escherichia coli]
ATGAGTACAGCCCTTTCCCCGATAATTTCTGAATTTGAAACAGTCGAACAAGAAAACAGCTATAACGAATGGTTGCGAAC
CAAAGTGGCAGCAAGCCTCTCAGATCCCCGTCCTGCAATTCCACATGACGAAGTAATGGCTGAAATGGAAAACCTTATTG
CTCAATTAGCTGCAACGAACAGGAGTGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7YS45

Antitoxin

Source ID Structure
AlphaFold DB A0A0D7Y007

References