Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | sanaTA/AbiEii-DUF6088 |
Location | 860154..861435 | Replicon | chromosome |
Accession | NZ_AP022069 | ||
Organism | Escherichia coli strain WP4-W18-ESBL-09 |
Toxin (Protein)
Gene name | sanaT | Uniprot ID | A0A1X3JHM4 |
Locus tag | H7R28_RS04015 | Protein ID | WP_001114681.1 |
Coordinates | 860154..861047 (-) | Length | 298 a.a. |
Antitoxin (Protein)
Gene name | sanaA | Uniprot ID | V0YCI1 |
Locus tag | H7R28_RS04020 | Protein ID | WP_000208383.1 |
Coordinates | 861040..861435 (-) | Length | 132 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H7R28_RS26995 | 855339..855665 | + | 327 | WP_000165313.1 | IS3 family transposase | - |
H7R28_RS27000 | 855665..856144 | + | 480 | WP_001130169.1 | transposase | - |
H7R28_RS03995 | 856751..858258 | + | 1508 | Protein_785 | group II intron reverse transcriptase/maturase | - |
H7R28_RS04000 | 858348..858821 | + | 474 | Protein_786 | IS3 family transposase | - |
H7R28_RS04005 | 858862..859164 | - | 303 | Protein_787 | IS21 family transposase | - |
H7R28_RS04010 | 859513..859683 | - | 171 | Protein_788 | IS110 family transposase | - |
H7R28_RS04015 | 860154..861047 | - | 894 | WP_001114681.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
H7R28_RS04020 | 861040..861435 | - | 396 | WP_000208383.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
H7R28_RS04025 | 861504..862349 | - | 846 | WP_001529401.1 | DUF4942 domain-containing protein | - |
H7R28_RS04030 | 862434..862631 | - | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
H7R28_RS04035 | 862648..863136 | - | 489 | WP_000761699.1 | hypothetical protein | - |
H7R28_RS04040 | 863133..863510 | - | 378 | WP_000854689.1 | TA system toxin CbtA family protein | - |
H7R28_RS04045 | 863587..863967 | - | 381 | WP_001285598.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
H7R28_RS04050 | 864017..864661 | - | 645 | WP_021566525.1 | hypothetical protein | - |
H7R28_RS04055 | 864680..864901 | - | 222 | WP_000692300.1 | DUF987 domain-containing protein | - |
H7R28_RS04060 | 864964..865440 | - | 477 | WP_001186774.1 | RadC family protein | - |
H7R28_RS04065 | 865455..865940 | - | 486 | WP_000849565.1 | antirestriction protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 298 a.a. Molecular weight: 34298.40 Da Isoelectric Point: 5.9850
>T34353 WP_001114681.1 NZ_AP022069:c861047-860154 [Escherichia coli]
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN
Download Length: 894 bp
>T34353 NZ_AP022069:c861047-860154 [Escherichia coli]
ATGCCTGAATTAACATCATTATTTCCTGACGTTGCCGATGCACTGGATATTGAATCTGTCGCTATCGTCGAAAAAGATTA
TTTTGTGGTTGATCTTTTAAGATTATTAAAAGAAATAAAACCAGAAACACATACTCTCGTGTTTGCAGGTAGTACCGCAT
TATCAAAAGCAGGTATCTCGCTAAACAGAATGTCAGAAGATATTGATATAAAGCTCGTGCCAACAGAGAACTTTATGCAA
AATGGCAGAGACAAGAGAAGAAAAATTCGCAAGGAAATCGTGCAAATAATCACGGATGTTATTCATAATTCTGACATTTT
CAGCTTGGATAATGAAAACGCCCGTATAACACGTGATGAGTATCGTTATAACGAAATCTCGGTACGTTATCCCCAGACAT
TTGCACAAGTCCCCTGTCTTCGTCCATTTATTAAGCTGGAGTTGATGGAAAGCACTCTGCTGGAACATCCGGAAAGCAGA
GATATTTATTCCCTTGTAACGGAGTTAACGGGTAAAGGTACACCTATAACAGCATTCCCCTGTGCCACCATTTTATCCAC
TCAGGCTGAAAAGCTCATCTCCATGATGCGAAGAACAGCAGCACATCTTCGTAATCCCGAACAACAGGATGATGAGTTTC
TGGTACGTCACATTTATGACAACTACTGCATTGTCAGGGAAAAAGGTGTGAATGTTCCTGTATTGAAAAATTTTGTTCAG
ATATGTATTCAACAGGATATTGAACGCTATGGTAACCAGTACCCACAATTTTGTAGCTCACCAGTTGATGAACTTAAGAA
AGGGCTGGATGCACTCCGGGATTATCCTGTACACAAATTGCGCTTTCAACGATTTGTTAACCCGATGGTATTTGGTAATA
CACAGATTAACTAG
ATGCCTGAATTAACATCATTATTTCCTGACGTTGCCGATGCACTGGATATTGAATCTGTCGCTATCGTCGAAAAAGATTA
TTTTGTGGTTGATCTTTTAAGATTATTAAAAGAAATAAAACCAGAAACACATACTCTCGTGTTTGCAGGTAGTACCGCAT
TATCAAAAGCAGGTATCTCGCTAAACAGAATGTCAGAAGATATTGATATAAAGCTCGTGCCAACAGAGAACTTTATGCAA
AATGGCAGAGACAAGAGAAGAAAAATTCGCAAGGAAATCGTGCAAATAATCACGGATGTTATTCATAATTCTGACATTTT
CAGCTTGGATAATGAAAACGCCCGTATAACACGTGATGAGTATCGTTATAACGAAATCTCGGTACGTTATCCCCAGACAT
TTGCACAAGTCCCCTGTCTTCGTCCATTTATTAAGCTGGAGTTGATGGAAAGCACTCTGCTGGAACATCCGGAAAGCAGA
GATATTTATTCCCTTGTAACGGAGTTAACGGGTAAAGGTACACCTATAACAGCATTCCCCTGTGCCACCATTTTATCCAC
TCAGGCTGAAAAGCTCATCTCCATGATGCGAAGAACAGCAGCACATCTTCGTAATCCCGAACAACAGGATGATGAGTTTC
TGGTACGTCACATTTATGACAACTACTGCATTGTCAGGGAAAAAGGTGTGAATGTTCCTGTATTGAAAAATTTTGTTCAG
ATATGTATTCAACAGGATATTGAACGCTATGGTAACCAGTACCCACAATTTTGTAGCTCACCAGTTGATGAACTTAAGAA
AGGGCTGGATGCACTCCGGGATTATCCTGTACACAAATTGCGCTTTCAACGATTTGTTAACCCGATGGTATTTGGTAATA
CACAGATTAACTAG
Antitoxin
Download Length: 132 a.a. Molecular weight: 14608.03 Da Isoelectric Point: 11.3150
>AT34353 WP_000208383.1 NZ_AP022069:c861435-861040 [Escherichia coli]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA
Download Length: 396 bp
>AT34353 NZ_AP022069:c861435-861040 [Escherichia coli]
ATGACTACAAAAGACCGTATTCAGTCCCGACTGAACCGTTCAAAACGTTATGTGTTCACCCGGGATGATTTCAGGGATAT
CGCTGGCTATGATCAGGTTGGCAGAGCTCTTCGTACACTGGTAAACGAAGGTAAGTTGATGAAAGTGGGCTATGGTGTTT
ACACCAAAGCCCGTCGTAACATCATCACTGGGAAAATCATGCCCGCAGCGCCTGGGGGCTCTGCTGCAGTAATTACAGAG
GCCCTGGAGCGCCTGAATATCAGATACCGTCTGGCAGGAGCAACGGAATGCTACAATAAAGGTCAGTCCACACAAATTCC
TGTATCTCTGGGGATAAAAACACCTTCTCGATTTAAAAGAGTGTTAATAGTAGGGAAAAGTAAAATCAATGCCTGA
ATGACTACAAAAGACCGTATTCAGTCCCGACTGAACCGTTCAAAACGTTATGTGTTCACCCGGGATGATTTCAGGGATAT
CGCTGGCTATGATCAGGTTGGCAGAGCTCTTCGTACACTGGTAAACGAAGGTAAGTTGATGAAAGTGGGCTATGGTGTTT
ACACCAAAGCCCGTCGTAACATCATCACTGGGAAAATCATGCCCGCAGCGCCTGGGGGCTCTGCTGCAGTAATTACAGAG
GCCCTGGAGCGCCTGAATATCAGATACCGTCTGGCAGGAGCAACGGAATGCTACAATAAAGGTCAGTCCACACAAATTCC
TGTATCTCTGGGGATAAAAACACCTTCTCGATTTAAAAGAGTGTTAATAGTAGGGAAAAGTAAAATCAATGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1X3JHM4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | V0YCI1 |