Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3866290..3866944 Replicon chromosome
Accession NZ_AP022064
Organism Escherichia coli strain WP4-W18-ESBL-08

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag H7R03_RS18720 Protein ID WP_000244765.1
Coordinates 3866290..3866697 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag H7R03_RS18725 Protein ID WP_000354050.1
Coordinates 3866678..3866944 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R03_RS18700 3862247..3863980 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
H7R03_RS18705 3863986..3864696 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H7R03_RS18710 3864721..3865617 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
H7R03_RS18715 3865729..3866250 + 522 WP_001055874.1 flavodoxin FldB -
H7R03_RS18720 3866290..3866697 - 408 WP_000244765.1 protein YgfX Toxin
H7R03_RS18725 3866678..3866944 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
H7R03_RS18730 3867187..3868167 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
H7R03_RS18735 3868244..3868903 - 660 WP_000250275.1 hemolysin III family protein -
H7R03_RS18740 3869067..3869378 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
H7R03_RS18745 3869423..3870856 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T34330 WP_000244765.1 NZ_AP022064:c3866697-3866290 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T34330 NZ_AP022064:c3866697-3866290 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT34330 WP_000354050.1 NZ_AP022064:c3866944-3866678 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT34330 NZ_AP022064:c3866944-3866678 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References