34313

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1231755..1232373 Replicon chromosome
Accession NZ_AP022064
Organism Escherichia coli strain WP4-W18-ESBL-08

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag H7R03_RS05915 Protein ID WP_001291435.1
Coordinates 1231755..1231973 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag H7R03_RS05920 Protein ID WP_000344800.1
Coordinates 1231999..1232373 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R03_RS05880 1227042..1227614 + 573 WP_000779831.1 YbaY family lipoprotein -
H7R03_RS05885 1227645..1227956 - 312 WP_000409908.1 MGMT family protein -
H7R03_RS05895 1228335..1228688 + 354 WP_000878135.1 DUF1428 family protein -
H7R03_RS05900 1228730..1230280 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
H7R03_RS05905 1230444..1230914 - 471 WP_000136192.1 YlaC family protein -
H7R03_RS05910 1231030..1231581 - 552 WP_000102539.1 maltose O-acetyltransferase -
H7R03_RS05915 1231755..1231973 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
H7R03_RS05920 1231999..1232373 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
H7R03_RS05925 1232919..1236068 - 3150 WP_001132478.1 multidrug efflux RND transporter permease subunit -
H7R03_RS05930 1236091..1237284 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T34313 WP_001291435.1 NZ_AP022064:c1231973-1231755 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T34313 NZ_AP022064:c1231973-1231755 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT34313 WP_000344800.1 NZ_AP022064:c1232373-1231999 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT34313 NZ_AP022064:c1232373-1231999 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References