Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4911503..4912119 Replicon chromosome
Accession NZ_AP022057
Organism Klebsiella sp. WP4-W18-ESBL-05

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H7R58_RS23390 Protein ID WP_106929282.1
Coordinates 4911503..4911874 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H7R58_RS23395 Protein ID WP_181358031.1
Coordinates 4911871..4912119 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R58_RS23375 4909007..4909909 + 903 WP_106929286.1 formate dehydrogenase subunit beta -
H7R58_RS23380 4909906..4910541 + 636 WP_006179126.1 formate dehydrogenase cytochrome b556 subunit -
H7R58_RS23385 4910538..4911467 + 930 WP_106929284.1 formate dehydrogenase accessory protein FdhE -
H7R58_RS23390 4911503..4911874 - 372 WP_106929282.1 type II toxin-antitoxin system VapC family toxin Toxin
H7R58_RS23395 4911871..4912119 - 249 WP_181358031.1 ribbon-helix-helix domain-containing protein Antitoxin
H7R58_RS23400 4912372..4913592 + 1221 WP_000343760.1 ISL3-like element ISKox3 family transposase -
H7R58_RS23405 4913649..4914560 + 912 WP_182929734.1 alpha/beta hydrolase -
H7R58_RS23410 4914584..4915525 - 942 WP_181358030.1 fatty acid biosynthesis protein FabY -
H7R58_RS23415 4915570..4916007 - 438 WP_106929276.1 D-tyrosyl-tRNA(Tyr) deacylase -
H7R58_RS23420 4916004..4916870 - 867 WP_106929274.1 virulence factor BrkB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4902116..4913592 11476
- flank IS/Tn - - 4912372..4913592 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14118.53 Da        Isoelectric Point: 9.5896

>T34305 WP_106929282.1 NZ_AP022057:c4911874-4911503 [Klebsiella sp. WP4-W18-ESBL-05]
MKRPVLFDTNILIDLFSGRMEAKRAMDSYPPQHAISLITWMEVMIGAKRFHQEQRTRIALSAFEIIGVTEEIAEQSVNLR
QEYGMKLPDAIILATAHVHRRELVTRNTKDFARLPGVILPYAL

Download         Length: 372 bp

>T34305 NZ_AP022057:c4911874-4911503 [Klebsiella sp. WP4-W18-ESBL-05]
ATGAAAAGACCCGTTCTTTTTGATACCAATATTTTAATCGATCTCTTCAGCGGGCGGATGGAGGCGAAGCGGGCGATGGA
TTCCTACCCTCCGCAACATGCGATAAGCCTGATCACCTGGATGGAGGTCATGATAGGGGCAAAGCGCTTTCATCAGGAGC
AGCGAACGCGAATAGCCTTGAGCGCATTCGAAATTATTGGTGTGACAGAAGAAATTGCTGAGCAGAGTGTGAATCTACGG
CAGGAGTACGGCATGAAGCTGCCCGATGCGATTATTCTGGCCACTGCGCATGTTCATCGCCGGGAACTGGTGACGCGTAA
TACAAAGGATTTTGCGAGGCTTCCGGGCGTGATTTTACCCTACGCGCTGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9746.13 Da        Isoelectric Point: 4.4777

>AT34305 WP_181358031.1 NZ_AP022057:c4912119-4911871 [Klebsiella sp. WP4-W18-ESBL-05]
MMVERDMGRILLDLSDEVIKRLDILKQQRNLPRAELLREAVEQYLEKQSQAELTISGALGIWQGCEEDGVEYERKLREEW
QR

Download         Length: 249 bp

>AT34305 NZ_AP022057:c4912119-4911871 [Klebsiella sp. WP4-W18-ESBL-05]
ATGATGGTGGAAAGGGACATGGGCAGAATACTTCTCGATTTGTCGGACGAGGTGATTAAGCGCCTCGACATACTTAAACA
GCAGCGAAATCTGCCTCGTGCGGAACTGCTGCGTGAAGCCGTTGAGCAATATCTTGAAAAGCAGAGTCAGGCTGAGCTCA
CTATTTCTGGCGCGCTTGGCATCTGGCAAGGGTGTGAAGAAGATGGCGTTGAGTATGAAAGAAAACTTCGGGAAGAGTGG
CAGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References