Detailed information of TA system TA034292

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1240611..1241229
• Replicon: chromosome
• Accession: NZ_AP022057
• Organism: Klebsiella sp. WP4-W18-ESBL-05

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: A0A1B7JI95
• Locus tag: H7R58_RS05935
• Protein ID: WP_064547995.1
• Coordinates: 1240611..1240829 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: H7R58_RS05940
• Protein ID: WP_106927922.1
• Coordinates: 1240855..1241229 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R58_RS05905	1236720..1236983	+	264	WP_106927932.1	type B 50S ribosomal protein L31	-
H7R58_RS05910	1236983..1237123	+	141	WP_003859006.1	type B 50S ribosomal protein L36	-
H7R58_RS05915	1237120..1237818	-	699	WP_106927930.1	GNAT family N-acetyltransferase	-
H7R58_RS05920	1237922..1239379	+	1458	WP_106927928.1	PLP-dependent aminotransferase family protein	-
H7R58_RS05925	1239348..1239818	-	471	WP_106927926.1	hypothetical protein	-
H7R58_RS05930	1239921..1240478	-	558	WP_106927924.1	maltose O-acetyltransferase	-
H7R58_RS05935	1240611..1240829	-	219	WP_064547995.1	hemolysin expression modulator Hha	Toxin
H7R58_RS05940	1240855..1241229	-	375	WP_106927922.1	Hha toxicity modulator TomB	Antitoxin
H7R58_RS05945	1241765..1244911	-	3147	WP_182929375.1	multidrug efflux RND transporter permease subunit AcrB	-
H7R58_RS05950	1244934..1246130	-	1197	WP_106930570.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-115)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8629.97 Da
• Isoelectric Point: 8.8580

>T34292 WP_064547995.1 NZ_AP022057:c1240829-1240611 [Klebsiella sp. WP4-W18-ESBL-05]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSTVWKYIR

Nucleotide

• Length: 219 bp

>T34292 NZ_AP022057:c1240829-1240611 [Klebsiella sp. WP4-W18-ESBL-05]
ATGTCTGATAAACCACTAACTAAAACTGATTATTTGATGCGCCTGCGACGCTGCCAGTCTATTGACACGCTCGAACGCGT
AATTGAAAAAAATAAATATGAGCTGTCCGACAATGAACTGGCGGTATTTTACTCAGCGGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAACTCTACGATAAGATCCCTTCAACCGTGTGGAAGTACATTCGCTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14383.21 Da
• Isoelectric Point: 4.8886

>AT34292 WP_106927922.1 NZ_AP022057:c1241229-1240855 [Klebsiella sp. WP4-W18-ESBL-05]
MDEYSPKRHDIAQLKFLCETLYHDCLATLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYDEDNKLIAQIDEYL
DDTFMLFSNYGINSVDLQKWRKSGNKLFRCFVNASRANPVSLSC

Nucleotide

• Length: 375 bp

>AT34292 NZ_AP022057:c1241229-1240855 [Klebsiella sp. WP4-W18-ESBL-05]
ATGGACGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGATTGTCTTGC
CACGCTCGAAGAGAGTAACCATGGCTGGGTGAACGATCCCACCTCGGCGGTTAACCTGCAGCTTAATGAGCTGATAGAAC
ATATAGCAACGTTCGCACTTAATTATAAAATTAAGTACGACGAAGATAATAAACTGATTGCACAGATTGACGAATATCTG
GATGATACTTTTATGTTATTCAGTAACTACGGCATTAATAGCGTCGACCTGCAAAAATGGCGGAAGTCAGGGAACAAACT
CTTCCGTTGTTTTGTCAATGCGAGCCGCGCCAACCCCGTCAGTCTTTCTTGTTAA

Structures

Toxin

• AlphaFold DB: A0A1B7JI95