Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4326..4848 Replicon plasmid pWP3-W19-ESBL-03_1
Accession NZ_AP022039
Organism Aeromonas veronii strain WP3-W19-ESBL-03

Toxin (Protein)


Gene name relE Uniprot ID A0A0S1GNF6
Locus tag H7R62_RS22980 Protein ID WP_017411297.1
Coordinates 4558..4848 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0S1GNF0
Locus tag H7R62_RS22975 Protein ID WP_026080514.1
Coordinates 4326..4568 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R62_RS22950 101..1318 - 1218 WP_017411290.1 tetracycline efflux MFS transporter Tet(E) -
H7R62_RS22955 1399..2031 + 633 WP_017411289.1 tetracycline resistance transcriptional repressor TetR(E) -
H7R62_RS22960 2418..3398 - 981 WP_139743098.1 hypothetical protein -
H7R62_RS22965 3549..3788 + 240 WP_016946643.1 CopG family ribbon-helix-helix protein -
H7R62_RS22970 3778..4062 + 285 WP_017411299.1 type II toxin-antitoxin system RelE/ParE family toxin -
H7R62_RS22975 4326..4568 + 243 WP_026080514.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H7R62_RS22980 4558..4848 + 291 WP_017411297.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7R62_RS22985 5084..6058 + 975 WP_014343694.1 replication initiation protein -
H7R62_RS22990 6202..6492 - 291 WP_017411295.1 hypothetical protein -
H7R62_RS22995 6691..7104 + 414 WP_017411294.1 plasmid mobilization relaxosome protein MobC -
H7R62_RS23000 7094..8653 + 1560 WP_080602841.1 relaxase/mobilization nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(E) / blaTEM-1B / blaCTX-M-3 - 1..17349 17349


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-85)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(2-62)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11352.14 Da        Isoelectric Point: 10.1879

>T34228 WP_017411297.1 NZ_AP022039:4558-4848 [Aeromonas veronii]
MTFELEFDPRAWKEWKKLGDTVRQQFKKKLAEVLERPRVEANRLHGLPDCYKIKLRGAGYRLVYQVQDERVLVFVVAVGK
REREQVYLDAGSRVNS

Download         Length: 291 bp

>T34228 NZ_AP022039:4558-4848 [Aeromonas veronii]
ATGACCTTTGAGCTTGAGTTCGATCCACGAGCGTGGAAGGAGTGGAAGAAGCTGGGTGATACCGTGCGCCAGCAGTTCAA
AAAGAAGCTCGCAGAGGTACTGGAGCGACCGAGGGTCGAGGCCAACCGCCTGCATGGGCTGCCGGACTGCTACAAGATCA
AGCTGCGTGGGGCGGGTTATCGGTTGGTTTACCAGGTGCAGGATGAGCGGGTGCTGGTATTCGTGGTCGCGGTGGGGAAA
CGAGAGCGGGAGCAGGTGTATCTGGACGCGGGATCGCGTGTGAATAGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9057.37 Da        Isoelectric Point: 4.6017

>AT34228 WP_026080514.1 NZ_AP022039:4326-4568 [Aeromonas veronii]
MGTINLRIDDDLKTRSYAVLEKLGVTPSELLRQTLEYVASQERLPFRTTVVTEDEEALLALVRERLASPQKGIRVSLDDL

Download         Length: 243 bp

>AT34228 NZ_AP022039:4326-4568 [Aeromonas veronii]
ATGGGCACGATCAATCTTCGCATCGACGACGATCTTAAGACTCGTTCGTATGCTGTCCTTGAAAAACTGGGCGTAACCCC
CTCGGAGCTGCTGCGGCAAACCCTGGAGTATGTTGCTTCCCAGGAGCGGTTGCCGTTTCGGACGACCGTGGTAACGGAGG
ATGAGGAGGCGCTGCTTGCCCTCGTTCGTGAGCGGCTGGCCAGCCCCCAGAAAGGGATCAGGGTGTCGCTGGATGACCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S1GNF6

Antitoxin

Source ID Structure
AlphaFold DB A0A0S1GNF0

References