Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 4326..4848 | Replicon | plasmid pWP3-W19-ESBL-03_1 |
Accession | NZ_AP022039 | ||
Organism | Aeromonas veronii strain WP3-W19-ESBL-03 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A0S1GNF6 |
Locus tag | H7R62_RS22980 | Protein ID | WP_017411297.1 |
Coordinates | 4558..4848 (+) | Length | 97 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A0S1GNF0 |
Locus tag | H7R62_RS22975 | Protein ID | WP_026080514.1 |
Coordinates | 4326..4568 (+) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H7R62_RS22950 | 101..1318 | - | 1218 | WP_017411290.1 | tetracycline efflux MFS transporter Tet(E) | - |
H7R62_RS22955 | 1399..2031 | + | 633 | WP_017411289.1 | tetracycline resistance transcriptional repressor TetR(E) | - |
H7R62_RS22960 | 2418..3398 | - | 981 | WP_139743098.1 | hypothetical protein | - |
H7R62_RS22965 | 3549..3788 | + | 240 | WP_016946643.1 | CopG family ribbon-helix-helix protein | - |
H7R62_RS22970 | 3778..4062 | + | 285 | WP_017411299.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
H7R62_RS22975 | 4326..4568 | + | 243 | WP_026080514.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
H7R62_RS22980 | 4558..4848 | + | 291 | WP_017411297.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
H7R62_RS22985 | 5084..6058 | + | 975 | WP_014343694.1 | replication initiation protein | - |
H7R62_RS22990 | 6202..6492 | - | 291 | WP_017411295.1 | hypothetical protein | - |
H7R62_RS22995 | 6691..7104 | + | 414 | WP_017411294.1 | plasmid mobilization relaxosome protein MobC | - |
H7R62_RS23000 | 7094..8653 | + | 1560 | WP_080602841.1 | relaxase/mobilization nuclease domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | tet(E) / blaTEM-1B / blaCTX-M-3 | - | 1..17349 | 17349 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11352.14 Da Isoelectric Point: 10.1879
>T34228 WP_017411297.1 NZ_AP022039:4558-4848 [Aeromonas veronii]
MTFELEFDPRAWKEWKKLGDTVRQQFKKKLAEVLERPRVEANRLHGLPDCYKIKLRGAGYRLVYQVQDERVLVFVVAVGK
REREQVYLDAGSRVNS
MTFELEFDPRAWKEWKKLGDTVRQQFKKKLAEVLERPRVEANRLHGLPDCYKIKLRGAGYRLVYQVQDERVLVFVVAVGK
REREQVYLDAGSRVNS
Download Length: 291 bp
>T34228 NZ_AP022039:4558-4848 [Aeromonas veronii]
ATGACCTTTGAGCTTGAGTTCGATCCACGAGCGTGGAAGGAGTGGAAGAAGCTGGGTGATACCGTGCGCCAGCAGTTCAA
AAAGAAGCTCGCAGAGGTACTGGAGCGACCGAGGGTCGAGGCCAACCGCCTGCATGGGCTGCCGGACTGCTACAAGATCA
AGCTGCGTGGGGCGGGTTATCGGTTGGTTTACCAGGTGCAGGATGAGCGGGTGCTGGTATTCGTGGTCGCGGTGGGGAAA
CGAGAGCGGGAGCAGGTGTATCTGGACGCGGGATCGCGTGTGAATAGCTGA
ATGACCTTTGAGCTTGAGTTCGATCCACGAGCGTGGAAGGAGTGGAAGAAGCTGGGTGATACCGTGCGCCAGCAGTTCAA
AAAGAAGCTCGCAGAGGTACTGGAGCGACCGAGGGTCGAGGCCAACCGCCTGCATGGGCTGCCGGACTGCTACAAGATCA
AGCTGCGTGGGGCGGGTTATCGGTTGGTTTACCAGGTGCAGGATGAGCGGGTGCTGGTATTCGTGGTCGCGGTGGGGAAA
CGAGAGCGGGAGCAGGTGTATCTGGACGCGGGATCGCGTGTGAATAGCTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9057.37 Da Isoelectric Point: 4.6017
>AT34228 WP_026080514.1 NZ_AP022039:4326-4568 [Aeromonas veronii]
MGTINLRIDDDLKTRSYAVLEKLGVTPSELLRQTLEYVASQERLPFRTTVVTEDEEALLALVRERLASPQKGIRVSLDDL
MGTINLRIDDDLKTRSYAVLEKLGVTPSELLRQTLEYVASQERLPFRTTVVTEDEEALLALVRERLASPQKGIRVSLDDL
Download Length: 243 bp
>AT34228 NZ_AP022039:4326-4568 [Aeromonas veronii]
ATGGGCACGATCAATCTTCGCATCGACGACGATCTTAAGACTCGTTCGTATGCTGTCCTTGAAAAACTGGGCGTAACCCC
CTCGGAGCTGCTGCGGCAAACCCTGGAGTATGTTGCTTCCCAGGAGCGGTTGCCGTTTCGGACGACCGTGGTAACGGAGG
ATGAGGAGGCGCTGCTTGCCCTCGTTCGTGAGCGGCTGGCCAGCCCCCAGAAAGGGATCAGGGTGTCGCTGGATGACCTT
TGA
ATGGGCACGATCAATCTTCGCATCGACGACGATCTTAAGACTCGTTCGTATGCTGTCCTTGAAAAACTGGGCGTAACCCC
CTCGGAGCTGCTGCGGCAAACCCTGGAGTATGTTGCTTCCCAGGAGCGGTTGCCGTTTCGGACGACCGTGGTAACGGAGG
ATGAGGAGGCGCTGCTTGCCCTCGTTCGTGAGCGGCTGGCCAGCCCCCAGAAAGGGATCAGGGTGTCGCTGGATGACCTT
TGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0S1GNF6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0S1GNF0 |