Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 3840565..3841133 Replicon chromosome
Accession NZ_AP022013
Organism Aeromonas caviae strain WP3-S18-ESBL-02

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag H7X73_RS18005 Protein ID WP_101617266.1
Coordinates 3840840..3841133 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag H7X73_RS18000 Protein ID WP_101617265.1
Coordinates 3840565..3840852 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7X73_RS17965 3835708..3836604 + 897 WP_011191354.1 LysR family transcriptional regulator -
H7X73_RS17970 3836601..3836840 - 240 WP_018429611.1 DUF2274 domain-containing protein -
H7X73_RS17975 3836840..3838060 - 1221 WP_011191355.1 TrbI/VirB10 family protein -
H7X73_RS17980 3838057..3839106 - 1050 WP_011191356.1 P-type conjugative transfer protein TrbG -
H7X73_RS17985 3839103..3839420 - 318 Protein_3484 conjugal transfer protein TrbF -
H7X73_RS17990 3839513..3839710 - 198 WP_161508007.1 chromosome partitioning protein ParB -
H7X73_RS17995 3839731..3840360 - 630 WP_182935892.1 AAA family ATPase -
H7X73_RS18000 3840565..3840852 + 288 WP_101617265.1 CopG family ribbon-helix-helix protein Antitoxin
H7X73_RS18005 3840840..3841133 + 294 WP_101617266.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7X73_RS18010 3841341..3841724 + 384 WP_139743097.1 hypothetical protein -
H7X73_RS18015 3841745..3842017 + 273 WP_139743096.1 hypothetical protein -
H7X73_RS18020 3842455..3843837 - 1383 WP_182935891.1 SEL1-like repeat protein -
H7X73_RS18025 3843868..3845136 - 1269 WP_011191342.1 IS4-like element ISApu1 family transposase -
H7X73_RS18030 3845390..3845920 + 531 WP_041212474.1 molybdopterin adenylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3800165..3845136 44971
- flank IS/Tn - - 3843868..3845136 1268


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(8-45)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10980.79 Da        Isoelectric Point: 10.6871

>T34117 WP_101617266.1 NZ_AP022013:3840840-3841133 [Aeromonas caviae]
MPPVIFAPAALRDLQRLREFLRPKSPQVAQRAATTIQLSLRQLAAQPSMGRPIEGLPEAFREWVIPFGDSGYLARYRIEP
DVIVVLAVRHQREVGYS

Download         Length: 294 bp

>T34117 NZ_AP022013:3840840-3841133 [Aeromonas caviae]
ATGCCACCAGTGATCTTTGCCCCTGCCGCCCTGCGAGACCTGCAACGCCTACGTGAATTCCTGCGCCCTAAAAGCCCGCA
GGTCGCACAGCGGGCCGCAACAACAATCCAGCTGTCCCTACGCCAGCTCGCAGCCCAACCCTCAATGGGCCGCCCCATAG
AAGGACTGCCAGAGGCGTTTCGTGAGTGGGTGATCCCCTTTGGTGACAGCGGCTATTTAGCCCGCTATCGCATTGAACCG
GATGTCATCGTGGTGCTCGCTGTCCGCCATCAACGCGAAGTTGGCTACTCATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11047.15 Da        Isoelectric Point: 4.7091

>AT34117 WP_101617265.1 NZ_AP022013:3840565-3840852 [Aeromonas caviae]
MPTQSKPVSIKLDADTQERIKRLATSRERSAHWLMREAISQYVEREELRETFHRDTLEAWQEFQETGQYATAQDVDQWLA
SWGTDAEGAPPACHQ

Download         Length: 288 bp

>AT34117 NZ_AP022013:3840565-3840852 [Aeromonas caviae]
ATGCCCACACAATCCAAACCGGTCTCGATCAAACTCGACGCCGATACCCAGGAACGCATCAAACGCCTGGCAACCTCCCG
CGAACGCTCAGCCCATTGGCTCATGCGCGAAGCCATCAGCCAGTATGTCGAGCGCGAAGAACTGCGCGAGACCTTCCACC
GCGACACTCTGGAGGCCTGGCAGGAGTTCCAGGAGACCGGCCAGTATGCCACCGCTCAAGATGTGGATCAGTGGCTAGCC
TCTTGGGGCACTGATGCCGAAGGAGCGCCTCCTGCATGCCACCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References