Detailed information of TA system TA034116

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 3425548..3426241
• Replicon: chromosome
• Accession: NZ_AP022013
• Organism: Aeromonas caviae strain WP3-S18-ESBL-02

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: H7X73_RS15900
• Protein ID: WP_000182276.1
• Coordinates: 3425548..3425904 (+)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: N2IIN5
• Locus tag: H7X73_RS15905
• Protein ID: WP_001172026.1
• Coordinates: 3425906..3426241 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7X73_RS15885	3420659..3421504	-	846	WP_003464995.1	AraC family transcriptional regulator	-
H7X73_RS15890	3421741..3424770	-	3030	WP_183148755.1	Tn3 family transposase	-
H7X73_RS15895	3424754..3425356	-	603	WP_010465829.1	recombinase family protein	-
H7X73_RS15900	3425548..3425904	+	357	WP_000182276.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H7X73_RS15905	3425906..3426241	+	336	WP_001172026.1	helix-turn-helix domain-containing protein	Antitoxin
H7X73_RS15910	3426256..3426591	+	336	WP_000741275.1	hypothetical protein	-
H7X73_RS15915	3426615..3426941	+	327	WP_000091614.1	hypothetical protein	-
H7X73_RS15920	3426938..3427318	+	381	WP_001054412.1	hypothetical protein	-
H7X73_RS15925	3427436..3427720	+	285	WP_130627582.1	DUF3391 domain-containing protein	-
H7X73_RS15930	3427767..3428681	+	915	WP_001736514.1	HD domain-containing protein	-
H7X73_RS15935	3428848..3429243	+	396	Protein_3089	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	sul1 / catB8 / blaGES-4 / aph(6)-Id / aph(3'')-Ib	-	3372412..3428681	56269

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (40-93)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 12912.93 Da
• Isoelectric Point: 8.9018

>T34116 WP_000182276.1 NZ_AP022013:3425548-3425904 [Aeromonas caviae]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKELKGFGGAGVLKVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQEL

Nucleotide

• Length: 357 bp

>T34116 NZ_AP022013:3425548-3425904 [Aeromonas caviae]
ATGACAAACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCCACAAGGATTTGATGGCGTTGCCGTCCGACGTGCGTCG
CCGTTTCGGTTACGCGCTCTCGTTGGCGCAGATAGGCGATCAGGATGACGCAGCAAAGGAGCTCAAGGGGTTCGGTGGTG
CCGGCGTGCTGAAGGTCGTCGAAGACGATGCCGGCGGCACCTATCGAGCGGTATACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGAATCGCCACGCCAAAGGCCGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGTATTGGCACAGGAGCTATGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12201.39 Da
• Isoelectric Point: 10.6058

>AT34116 WP_001172026.1 NZ_AP022013:3425906-3426241 [Aeromonas caviae]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Nucleotide

• Length: 336 bp

>AT34116 NZ_AP022013:3425906-3426241 [Aeromonas caviae]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAGCGCAGCTCGGGCAACGTCTTTGCCGACCTTGGACTGCCTGACGC
TGAAAAGCTCAAGATCAAGACCGGCCTGGTGGTCGAGATCAGGAGGGCCATGCGCGCCCTTGGGCTGACTCAACAAGCGG
CGGCCAAACGCATGGGCATCCCGCAACCGAAGGTGTCGGGCATGATGCGCGGCGACTTCACCAATCTATCCGAACGCAAG
CTGATGGATTGTCTGAATCGCCTCGGCTACGACATCGAAATCAAGGTACGGCCAGCAGCCGAGCCGATCGGGCATCTAAC
GCTCGCAACCGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A024EKI7