Detailed information of TA system TA034084

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4439159..4439979
• Replicon: chromosome
• Accession: NZ_AP022003
• Organism: Escherichia coli strain WP3-W18-ESBL-08

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A0V9MKL8
• Locus tag: H7R22_RS21360
• Protein ID: WP_001550554.1
• Coordinates: 4439159..4439416 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: H7R22_RS21365
• Protein ID: WP_001519303.1
• Coordinates: 4439428..4439979 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R22_RS21340	4434445..4435551	+	1107	WP_001519308.1	N-acetylneuraminate epimerase	-
H7R22_RS21345	4435616..4436596	+	981	WP_001519307.1	transposase	-
H7R22_RS21350	4437179..4438420	-	1242	Protein_4177	DNA helicase	-
H7R22_RS21355	4438483..4438782	+	300	WP_001519304.1	GNAT family N-acetyltransferase	-
H7R22_RS21360	4439159..4439416	+	258	WP_001550554.1	hypothetical protein	Toxin
H7R22_RS21365	4439428..4439979	+	552	WP_001519303.1	N-acetyltransferase	Antitoxin
H7R22_RS21370	4440031..4440192	+	162	WP_001519302.1	hypothetical protein	-
H7R22_RS21375	4440229..4440777	+	549	WP_001519301.1	hypothetical protein	-
H7R22_RS21380	4440904..4441164	+	261	WP_000084876.1	hypothetical protein	-
H7R22_RS25920	4441202..4441318	+	117	Protein_4184	VOC family protein	-
H7R22_RS21385	4441563..4442684	+	1122	WP_000010833.1	M42 family metallopeptidase	-
H7R22_RS21390	4442681..4442959	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
H7R22_RS21395	4442971..4444284	+	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB	4431643..4440192	8549

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9744.33 Da
• Isoelectric Point: 11.0090

>T34084 WP_001550554.1 NZ_AP022003:4439159-4439416 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKPVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T34084 NZ_AP022003:4439159-4439416 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGCCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT34084 WP_001519303.1 NZ_AP022003:4439428-4439979 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT34084 NZ_AP022003:4439428-4439979 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCGACCTTCAAAGGAGAAATGGATTCACCGCTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: A0A0V9MKL8