34067

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1988997..1989828 Replicon chromosome
Accession NZ_AP022003
Organism Escherichia coli strain WP3-W18-ESBL-08

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag H7R22_RS09465 Protein ID WP_000854814.1
Coordinates 1988997..1989371 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag H7R22_RS09470 Protein ID WP_001285585.1
Coordinates 1989460..1989828 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R22_RS09425 1984393..1985559 + 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
H7R22_RS09430 1985678..1986151 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
H7R22_RS09435 1986349..1987407 + 1059 WP_001200891.1 FUSC family protein -
H7R22_RS09440 1987579..1987908 + 330 WP_000450409.1 DUF496 family protein -
H7R22_RS09445 1988009..1988191 - 183 WP_001016348.1 hypothetical protein -
H7R22_RS09450 1988263..1988391 + 129 Protein_1849 transposase domain-containing protein -
H7R22_RS09455 1988680..1988793 - 114 WP_001161660.1 DUF957 domain-containing protein -
H7R22_RS09460 1988806..1989000 - 195 WP_000988600.1 hypothetical protein -
H7R22_RS09465 1988997..1989371 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
H7R22_RS09470 1989460..1989828 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
H7R22_RS09475 1989902..1990123 - 222 WP_000692323.1 DUF987 domain-containing protein -
H7R22_RS09480 1990186..1990662 - 477 WP_039267628.1 RadC family protein -
H7R22_RS09485 1990678..1991157 - 480 WP_000860087.1 antirestriction protein -
H7R22_RS09490 1991239..1992057 - 819 WP_060626401.1 DUF945 domain-containing protein -
H7R22_RS09495 1992157..1992390 - 234 WP_001119729.1 DUF905 family protein -
H7R22_RS09500 1992465..1992920 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T34067 WP_000854814.1 NZ_AP022003:c1989371-1988997 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T34067 NZ_AP022003:c1989371-1988997 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT34067 WP_001285585.1 NZ_AP022003:c1989828-1989460 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT34067 NZ_AP022003:c1989828-1989460 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References