Detailed information of TA system TA034048

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4209870..4210690
• Replicon: chromosome
• Accession: NZ_AP021998
• Organism: Escherichia coli strain WP3-W18-ESBL-07

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: H7Q99_RS20385
• Protein ID: WP_001054379.1
• Coordinates: 4209870..4210127 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: H7Q99_RS20390
• Protein ID: WP_000123957.1
• Coordinates: 4210139..4210690 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7Q99_RS20365	4205417..4206397	+	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
H7Q99_RS20370	4206980..4208086	-	1107	Protein_3994	DNA helicase	-
H7Q99_RS20375	4208149..4209296	+	1148	WP_085949154.1	IS3-like element ISEc52 family transposase	-
H7Q99_RS20380	4209329..4209493	+	165	Protein_3996	GNAT family N-acetyltransferase	-
H7Q99_RS20385	4209870..4210127	+	258	WP_001054379.1	YjhX family toxin	Toxin
H7Q99_RS20390	4210139..4210690	+	552	WP_000123957.1	N-acetyltransferase	Antitoxin
H7Q99_RS20395	4210742..4211488	+	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
H7Q99_RS20400	4211616..4211876	+	261	WP_000077645.1	hypothetical protein	-
H7Q99_RS24925	4211914..4212030	+	117	Protein_4001	VOC family protein	-
H7Q99_RS20405	4212275..4213396	+	1122	WP_000010833.1	M42 family metallopeptidase	-
H7Q99_RS20410	4213393..4213671	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
H7Q99_RS20415	4213683..4214996	+	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T34048 WP_001054379.1 NZ_AP021998:4209870-4210127 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T34048 NZ_AP021998:4209870-4210127 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT34048 WP_000123957.1 NZ_AP021998:4210139-4210690 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT34048 NZ_AP021998:4210139-4210690 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030