34033

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1900295..1901126 Replicon chromosome
Accession NZ_AP021998
Organism Escherichia coli strain WP3-W18-ESBL-07

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag H7Q99_RS08885 Protein ID WP_000854815.1
Coordinates 1900295..1900669 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag H7Q99_RS08890 Protein ID WP_001280918.1
Coordinates 1900758..1901126 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7Q99_RS08845 1895691..1896857 + 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
H7Q99_RS08850 1896976..1897449 + 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
H7Q99_RS08855 1897647..1898705 + 1059 WP_001200889.1 FUSC family protein -
H7Q99_RS08860 1898877..1899206 + 330 WP_000450409.1 DUF496 family protein -
H7Q99_RS08865 1899307..1899489 - 183 WP_001296208.1 hypothetical protein -
H7Q99_RS08870 1899543..1899689 + 147 Protein_1736 transposase domain-containing protein -
H7Q99_RS08875 1899978..1900091 - 114 WP_001161660.1 DUF957 domain-containing protein -
H7Q99_RS08880 1900104..1900298 - 195 WP_000988600.1 hypothetical protein -
H7Q99_RS08885 1900295..1900669 - 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
H7Q99_RS08890 1900758..1901126 - 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H7Q99_RS08895 1901142..1901786 - 645 WP_000086752.1 hypothetical protein -
H7Q99_RS08900 1901805..1902026 - 222 WP_000692345.1 DUF987 domain-containing protein -
H7Q99_RS08905 1902089..1902565 - 477 WP_001186200.1 RadC family protein -
H7Q99_RS08910 1902581..1903054 - 474 WP_001542276.1 antirestriction protein -
H7Q99_RS08915 1903148..1903393 - 246 WP_001164966.1 hypothetical protein -
H7Q99_RS08920 1903393..1904211 - 819 WP_001542275.1 DUF945 domain-containing protein -
H7Q99_RS08925 1904432..1904842 - 411 WP_000846703.1 hypothetical protein -
H7Q99_RS08930 1904858..1905208 - 351 Protein_1748 hypothetical protein -
H7Q99_RS08935 1905291..1906037 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T34033 WP_000854815.1 NZ_AP021998:c1900669-1900295 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T34033 NZ_AP021998:c1900669-1900295 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT34033 WP_001280918.1 NZ_AP021998:c1901126-1900758 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT34033 NZ_AP021998:c1901126-1900758 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References