Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 821925..822759 | Replicon | chromosome |
| Accession | NZ_AP021998 | ||
| Organism | Escherichia coli strain WP3-W18-ESBL-07 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PLF5 |
| Locus tag | H7Q99_RS03945 | Protein ID | WP_000854690.1 |
| Coordinates | 821925..822302 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1P7N8 |
| Locus tag | H7Q99_RS03950 | Protein ID | WP_001305076.1 |
| Coordinates | 822391..822759 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H7Q99_RS03915 | 818319..818474 | - | 156 | WP_000729638.1 | hypothetical protein | - |
| H7Q99_RS03920 | 818906..819839 | - | 934 | Protein_770 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| H7Q99_RS03925 | 819832..820227 | - | 396 | WP_000208384.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | - |
| H7Q99_RS03930 | 820296..821141 | - | 846 | WP_001529401.1 | DUF4942 domain-containing protein | - |
| H7Q99_RS03935 | 821226..821423 | - | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
| H7Q99_RS03940 | 821440..821928 | - | 489 | WP_000761699.1 | hypothetical protein | - |
| H7Q99_RS03945 | 821925..822302 | - | 378 | WP_000854690.1 | TA system toxin CbtA family protein | Toxin |
| H7Q99_RS03950 | 822391..822759 | - | 369 | WP_001305076.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| H7Q99_RS03955 | 822809..823453 | - | 645 | WP_000094916.1 | hypothetical protein | - |
| H7Q99_RS03960 | 823472..823693 | - | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| H7Q99_RS03965 | 823756..824232 | - | 477 | WP_001186726.1 | RadC family protein | - |
| H7Q99_RS03970 | 824248..824733 | - | 486 | WP_000849565.1 | antirestriction protein | - |
| H7Q99_RS03975 | 824788..825606 | - | 819 | WP_001234620.1 | DUF945 domain-containing protein | - |
| H7Q99_RS03980 | 825707..825940 | - | 234 | WP_000902034.1 | DUF905 family protein | - |
| H7Q99_RS03985 | 826019..826474 | - | 456 | WP_000581502.1 | hypothetical protein | - |
| H7Q99_RS03990 | 826550..827677 | - | 1128 | Protein_784 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | ugd / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF / sat | 802375..870972 | 68597 | |
| - | flank | IS/Tn | - | - | 818319..818474 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14057.04 Da Isoelectric Point: 9.1510
>T34030 WP_000854690.1 NZ_AP021998:c822302-821925 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T34030 NZ_AP021998:c822302-821925 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13560.39 Da Isoelectric Point: 4.7830
>AT34030 WP_001305076.1 NZ_AP021998:c822759-822391 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
Download Length: 369 bp
>AT34030 NZ_AP021998:c822759-822391 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|