Detailed information of TA system TA034014

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2518663..2519576
• Replicon: chromosome
• Accession: NZ_AP021983
• Organism: Raoultella ornithinolytica strain WP3-W18-ESBL-06

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A808Y4A8
• Locus tag: H7R89_RS11930
• Protein ID: WP_015584188.1
• Coordinates: 2518663..2519136 (-)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A808Y7A4
• Locus tag: H7R89_RS11935
• Protein ID: WP_004862777.1
• Coordinates: 2519133..2519576 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R89_RS11905	2514702..2515310	-	609	WP_032716409.1	glutathione S-transferase family protein	-
H7R89_RS11910	2515552..2516457	+	906	WP_032716408.1	transcriptional regulator GcvA	-
H7R89_RS11915	2516485..2517390	-	906	WP_126509578.1	LysR family transcriptional regulator	-
H7R89_RS11920	2517493..2517810	+	318	WP_180553818.1	nuclear transport factor 2 family protein	-
H7R89_RS11925	2517803..2518582	+	780	WP_182952419.1	SDR family oxidoreductase	-
H7R89_RS11930	2518663..2519136	-	474	WP_015584188.1	RES domain-containing protein	Toxin
H7R89_RS11935	2519133..2519576	-	444	WP_004862777.1	DUF2384 domain-containing protein	Antitoxin
H7R89_RS11940	2519766..2520332	-	567	WP_015584190.1	DJ-1/PfpI family protein	-
H7R89_RS11945	2520730..2521512	+	783	WP_032717546.1	DUF3750 domain-containing protein	-
H7R89_RS11950	2521709..2522933	+	1225	Protein_2335	zinc metallochaperone GTPase ZigA	-
H7R89_RS11970	2523864..2524343	-	480	WP_113991048.1	acid resistance repetitive basic protein Asr	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17524.82 Da
• Isoelectric Point: 4.8081

>T34014 WP_015584188.1 NZ_AP021983:c2519136-2518663 [Raoultella ornithinolytica]
MIFYRLVTGRYASEAWTGSGANQYGGRWNHQGHPAVYVSTSIALASLEILVHVKNEAILNQYQLYSIEIPDSEVESLDKQ
WLPDNWQENPMPVSTMDLGTGWLQSGSGLALMLPSCIIPYENNAILNPLHPAFSEALASVRQYPFTFDPRLARSTPL

Nucleotide

• Length: 474 bp

>T34014 NZ_AP021983:c2519136-2518663 [Raoultella ornithinolytica]
ATGATTTTCTATCGTCTGGTTACCGGCCGTTACGCCAGCGAAGCCTGGACGGGAAGCGGGGCCAACCAGTACGGCGGGCG
CTGGAATCACCAGGGACACCCGGCGGTCTATGTGTCCACTTCCATTGCCCTGGCGTCACTGGAGATCCTGGTTCACGTCA
AAAATGAGGCAATCCTCAACCAGTATCAGCTGTATAGTATCGAGATACCGGACAGTGAAGTGGAATCCCTCGATAAACAG
TGGTTACCGGATAACTGGCAAGAAAATCCGATGCCCGTTTCCACAATGGATCTGGGCACCGGCTGGCTACAGTCGGGCAG
CGGTCTGGCGCTGATGCTTCCCTCCTGCATTATTCCCTATGAAAACAACGCCATTTTAAACCCGCTGCATCCCGCGTTCA
GCGAGGCCCTGGCCTCCGTGCGTCAGTATCCCTTTACCTTTGATCCCCGCCTCGCACGCTCCACGCCCCTCTGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16190.45 Da
• Isoelectric Point: 4.9405

>AT34014 WP_004862777.1 NZ_AP021983:c2519576-2519133 [Raoultella ornithinolytica]
MKTWVPAEQPADNALWRYAGLPANRGMQLIELLSMGLPVSILDNIHEWTEMSKTDILRITGINERNVARRKSAGGTLTPG
ESERVARFVRVLDTAVDYFGSKQDAYDWLQSPVRGLGNVAPIDLIATESGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT34014 NZ_AP021983:c2519576-2519133 [Raoultella ornithinolytica]
ATGAAAACCTGGGTTCCTGCAGAGCAACCTGCCGATAATGCGCTGTGGCGCTATGCCGGGCTACCGGCGAATCGGGGTAT
GCAGTTGATTGAGCTGCTGAGTATGGGATTACCGGTCAGCATTCTGGATAATATTCATGAGTGGACGGAAATGTCGAAAA
CCGACATTCTGCGCATCACCGGGATTAATGAGCGCAACGTTGCCCGGCGCAAGAGCGCGGGCGGCACGTTGACGCCAGGC
GAAAGCGAACGTGTGGCGCGTTTTGTCAGGGTCCTGGATACCGCCGTCGACTATTTTGGCAGCAAGCAGGATGCCTACGA
CTGGCTGCAGTCGCCGGTCAGAGGACTGGGCAATGTCGCCCCCATCGACCTGATTGCTACCGAGAGCGGCGCGCTGGAAG
TAACAGACCTGATTGGTCGCCTGGAACACGGCGTCTTTGCATGA

Structures

Toxin

• AlphaFold DB: A0A808Y4A8

Antitoxin

• AlphaFold DB: A0A808Y7A4