Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 897500..898157 Replicon chromosome
Accession NZ_AP021983
Organism Raoultella ornithinolytica strain WP3-W18-ESBL-06

Toxin (Protein)


Gene name cptA Uniprot ID A0A808XTM6
Locus tag H7R89_RS04385 Protein ID WP_004867355.1
Coordinates 897747..898157 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A514ELX1
Locus tag H7R89_RS04380 Protein ID WP_004867358.1
Coordinates 897500..897766 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R89_RS04355 892634..894058 - 1425 WP_182952455.1 6-phospho-beta-glucosidase -
H7R89_RS04360 894188..894916 - 729 WP_004867368.1 MurR/RpiR family transcriptional regulator -
H7R89_RS04365 894966..895277 + 312 WP_004867365.1 N(4)-acetylcytidine aminohydrolase -
H7R89_RS04370 895439..896098 + 660 WP_004867362.1 hemolysin III family protein -
H7R89_RS04375 896220..897203 - 984 WP_015585783.1 tRNA-modifying protein YgfZ -
H7R89_RS04380 897500..897766 + 267 WP_004867358.1 FAD assembly factor SdhE Antitoxin
H7R89_RS04385 897747..898157 + 411 WP_004867355.1 protein YgfX Toxin
H7R89_RS04390 898165..898686 - 522 WP_004867353.1 flavodoxin FldB -
H7R89_RS04395 898865..899761 + 897 WP_015585784.1 site-specific tyrosine recombinase XerD -
H7R89_RS04400 899784..900497 + 714 WP_004867349.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H7R89_RS04405 900503..902236 + 1734 WP_165458960.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16226.16 Da        Isoelectric Point: 11.3349

>T34005 WP_004867355.1 NZ_AP021983:897747-898157 [Raoultella ornithinolytica]
VVLWQSDLRISWRSQWFSLLLHGIVAAIVLLMPWPLSYTPLWLLLLSLVVFDSVRSQRRIHACRGEIKLMTDSRLRWQKA
EWEIVGTPWVINSGMLLRLQDMQTRRRQHLWIAADSMDAKEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T34005 NZ_AP021983:897747-898157 [Raoultella ornithinolytica]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCCTGGCGCTCACAGTGGTTCTCGCTGCTGCTGCACGGCATTGTGGCGGC
TATTGTGCTGCTGATGCCCTGGCCGCTGAGCTACACGCCGCTATGGCTATTGCTGCTGTCGCTGGTGGTGTTCGACAGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCGGGGGGAAATAAAGCTGATGACCGATTCGCGTTTGCGTTGGCAAAAAGCG
GAATGGGAGATTGTCGGCACGCCGTGGGTGATTAATAGCGGGATGTTGCTGCGTCTGCAGGATATGCAAACGCGTCGCCG
CCAGCATCTGTGGATCGCTGCAGACAGTATGGACGCCAAAGAGTGGCGAGATCTGCGCCGGTTGGTGTTACAAAAACCGG
CACAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10553.05 Da        Isoelectric Point: 4.8432

>AT34005 WP_004867358.1 NZ_AP021983:897500-897766 [Raoultella ornithinolytica]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKQLFIRLLENDDPDLFNWLMNHGEPADAQLQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT34005 NZ_AP021983:897500-897766 [Raoultella ornithinolytica]
ATGGACATTACGAATAAAGCCCGCATCCACTGGGCATGCCGCAGGGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGATACGCTCAGCGATGAAGACAAACAGCTGTTTATCCGTCTGTTAGAAAACGACGATCCGGATC
TGTTTAACTGGCTGATGAATCATGGCGAACCGGCTGATGCGCAACTGCAACGGATGGTAAAATTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808XTM6

Antitoxin

Source ID Structure
AlphaFold DB A0A514ELX1

References